PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Pbr011903.3

Organism

Pyrus bretschneideri

Taxonomic ID

225117

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Pyrus

Family

E2F/DP

Protein Properties

Length: 535aa MW: 58834.3 Da PI: 4.7154

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Pbr011903.3	genome	CPETR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	85.9	3e-27	142	207	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r ++sL+llt+kf++l++++e+gi++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+i+wkg Pbr011903.3 142 RFDSSLGLLTKKFINLIKHAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 207 6789****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	9.8E-29	140	209	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	7.35E-17	142	205	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.1E-34	142	207	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	1.5E-24	144	207	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF144074	3.92E-32	219	324	No hit	No description
CDD	cd14660	8.80E-47	222	324	No hit	No description
Pfam	PF16421	1.1E-31	223	322	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 535 aa Download sequence Send to blast
MSGSRAPNPP AQPPQPVMQQ PLKRQLPFSS MKPPFSAAAD YHGFLPDPRQ TTDQETYGIT 60 VKTPLKRKSD AVDCEAESSD RTTAPGYTDV GNSLLQTPMS TKVGKANKTS RLTKCSKSGP 120 RTPASNVGSP SGANVTPAGP CRFDSSLGLL TKKFINLIKH AEDGILDLNK AADTLEVQKR 180 RIYDITNVLE GIGLIEKKLK NRIQWKGLDV SRTGDVDENY PSLQAQLENL SIEERRLDQQ 240 IREMQERLRD LSVDESNKKW LFVTEEDIKG LPCLQNETLI AIKAPHGTTL EVPDPDEAVD 300 YPQRRYRMVL RSTMGPIDVY LVSQFEEKFE EINGVEVPAN IPATSGANEN PATTMVSEDR 360 GKDVELQVPD DHTMSADPTA AQDFTGGIMK IVPSDVDSDT DYWLLSDADI SITDLWRTER 420 ILVPKDVIFL FTEFSLCLYL TGKQFLWVNF LTISTIAGVL WNDLGALDHD YPLGSGSCPS 480 VPGRPIEGTR NNVMVGGESN QQAFVGVTGV KKAGYRRIEN QSLDINAGAD ECIT*

Sequence ? help Back to Top

Protein Sequence Length: 535 aa Download sequence Send to blast

MSGSRAPNPP AQPPQPVMQQ PLKRQLPFSS MKPPFSAAAD YHGFLPDPRQ TTDQETYGIT  60
VKTPLKRKSD AVDCEAESSD RTTAPGYTDV GNSLLQTPMS TKVGKANKTS RLTKCSKSGP  120
RTPASNVGSP SGANVTPAGP CRFDSSLGLL TKKFINLIKH AEDGILDLNK AADTLEVQKR  180
RIYDITNVLE GIGLIEKKLK NRIQWKGLDV SRTGDVDENY PSLQAQLENL SIEERRLDQQ  240
IREMQERLRD LSVDESNKKW LFVTEEDIKG LPCLQNETLI AIKAPHGTTL EVPDPDEAVD  300
YPQRRYRMVL RSTMGPIDVY LVSQFEEKFE EINGVEVPAN IPATSGANEN PATTMVSEDR  360
GKDVELQVPD DHTMSADPTA AQDFTGGIMK IVPSDVDSDT DYWLLSDADI SITDLWRTER  420
ILVPKDVIFL FTEFSLCLYL TGKQFLWVNF LTISTIAGVL WNDLGALDHD YPLGSGSCPS  480
VPGRPIEGTR NNVMVGGESN QQAFVGVTGV KKAGYRRIEN QSLDINAGAD ECIT*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	4e-26	137	208	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Pbr011903.3

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_009369919.1	0.0	PREDICTED: transcription factor E2FB isoform X2
Swissprot	Q9FV71	1e-144	E2FB_ARATH; Transcription factor E2FB
TrEMBL	A0A498KBY8	0.0	A0A498KBY8_MALDO; Uncharacterized protein
STRING	XP_009369918.1	0.0	(Pyrus x bretschneideri)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF1947	34	90

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G22220.3	1e-146	E2F transcription factor 1

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]