PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Pp3c2_30010V3.2.p
Common NameE2F3, PHYPADRAFT_177212
Organism
Physcomitrella patens
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Bryophyta; Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrella
Family E2F/DP
Protein Properties Length: 401aa    MW: 44075.3 Da    PI: 4.7721
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Pp3c2_30010V3.2.pgenomeCOSMOSSView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.81.6e-2774139171
            E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                        r+++sL+llt+kf++l++++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
  Pp3c2_30010V3.2.p  74 RYDSSLGLLTKKFIDLIKQAEDGVLDLNKAADTL---HV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 139
                        6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.2E-2970140IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013728.0E-3574139IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467857.0E-1874137IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023196.1E-2576139IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146602.60E-48150255No hitNo description
SuperFamilySSF1440741.12E-31154255No hitNo description
PfamPF164212.8E-33155254IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000006anatomyplant protoplast
PO:0025017anatomyplant spore
PO:0030003anatomyprotonema
PO:0030018anatomygametophore
Sequence ? help Back to Top
Protein Sequence    Length: 401 aa     Download sequence    Send to blast
MKRRNECEEH HVEMNGWNGY ANSDLSPAPT PTGPRGRASR PKTVKQTKNG PQTPGPSGIG  60
SPTSSAPTPT STCRYDSSLG LLTKKFIDLI KQAEDGVLDL NKAADTLHVQ KRRIYDITNV  120
LEGIGLIEKK LKNRIRWKGL GMVRTTEGKD DAVGLQVEVE DLRNEEKKLD ESISEMRERL  180
RSLSEDDHNK QWLYVTEDDI KNLPCFQNET LIAIKAPLGT TLEVPDPDEA VEYPHRRFQI  240
LLRSTMGPID VYLVSRFEGR TEVPMEPLPG SQEAGPSTTA NAMDHQGNMA MVPEVGYGLS  300
DLVPPANHEA ASQTSEPTSS HPDFVGGIMR IAPAEGNTDS DYWLLSDAGV GISDMWRSDP  360
SNAMWDEVVR LNTEFGIENI GSPRPHTPPS SNALEVDPVS *
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A3e-2669141275PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Ppa.36050.0protonema
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant in early S phase. Decreased expression during the passage into G2. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543}.
UniprotTISSUE SPECIFICITY: Highly expressed in the shoot apical meristem, emerging leaf primordia, and vascular tissues of young leaf primordia. Expressed in flowers, in epidermis and cortex of hypocotyls, and at lower levels in leaves. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11889041}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAB5473390.0AB547339.1 Physcomitrella patens E2F;3 mRNA for E2F transcription factor;3, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024368554.10.0transcription factor E2FA-like isoform X1
RefseqXP_024368555.10.0transcription factor E2FA-like isoform X2
RefseqXP_024368556.10.0transcription factor E2FA-like isoform X2
SwissprotQ9FNY01e-105E2FA_ARATH; Transcription factor E2FA
TrEMBLA9RQX00.0A9RQX0_PHYPA; E2F transcription factor3
STRINGPP1S22_60V6.10.0(Physcomitrella patens)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-103E2F transcription factor 1
Publications ? help Back to Top
  1. Rensing SA, et al.
    The Physcomitrella genome reveals evolutionary insights into the conquest of land by plants.
    Science, 2008. 319(5859): p. 64-9
    [PMID:18079367]
  2. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]