PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID RrC14987_p2
Organism
Raphanus raphanistrum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Raphanus
Family E2F/DP
Protein Properties Length: 393aa    MW: 44090.4 Da    PI: 7.7236
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
RrC14987_p2genomeMSUView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP72.73.9e-233398171
      E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                 rk+ksL+ll+++fl+l+++   +++ l++++++L    v  +rRRiYDi+NVLe+++++++++kn+++wkg
  RrC14987_p2 33 RKQKSLGLLCTNFLALYNRHGIETIGLDDASSKL---GV--ERRRIYDIVNVLESVGVLTRRAKNQYTWKG 98
                 79*****************999************...**..****************************98 PP
2E2F_TDP79.43.3e-25168248171
      E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                  r+eksL+lltq+f+kl+ +s+++i++l+e+ak L+ +      +++k+RR+YDi+NVL+++nliek     ++k++++w g
  RrC14987_p2 168 RREKSLGLLTQNFIKLFICSQATIISLDEAAKLLLGDahntsIMRTKVRRLYDIANVLSSMNLIEKthtldSRKPAFKWLG 248
                  689**************************************999************************9999*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.109.0E-2629100IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.9E-163296IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.5E-283398IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.8E-203498IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.102.2E-23165249IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.2E-32168248IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023195.3E-20170248IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467857.0E-14170249IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 393 aa     Download sequence    Send to blast
MSDLPPEKPN MELSSSCSMP GSSSSSLHHS YSRKQKSLGL LCTNFLALYN RHGIETIGLD  60
DASSKLGVER RRIYDIVNVL ESVGVLTRRA KNQYTWKGFS AIPAALKELQ EEGAKDTFHR  120
FYTNENVKGS DDEDDEEESS SQPLSSSQTD TSKPASSPLP DSSKIDNRRE KSLGLLTQNF  180
IKLFICSQAT IISLDEAAKL LLGDAHNTSI MRTKVRRLYD IANVLSSMNL IEKTHTLDSR  240
KPAFKWLGYN GEPTFTLSSD LMMQAESKKR VFGTDLSNVS VKRSKTHDSA TERSLKMKQH  300
AIAESSYNRI FDALGSRGYE FGPFAPATGT YPTAPLEDNS KRAFDVQNLV SDYRPSYQNQ  360
VLKDLFGHYM DAWKSWYTEV TQKNPLPDTS QHH
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A6e-41322403228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_018458791.10.0PREDICTED: E2F transcription factor-like E2FE
SwissprotQ8LSZ40.0E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A398AWG10.0A0A398AWG1_BRACM; Uncharacterized protein
STRINGBo1g074680.10.0(Brassica oleracea)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM63042743
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.20.0DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]