PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID RrC7587_p1
Organism
Raphanus raphanistrum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Raphanus
Family E2F/DP
Protein Properties Length: 395aa    MW: 44470.6 Da    PI: 7.198
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
RrC7587_p1genomeMSUView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP73.12.9e-233297171
     E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                rk+ksL+ll+++fl+l+++   +++ l+++a++L    v  +rRRiYDi+NVLe+++++ k++kn+++w+g
  RrC7587_p1 32 RKQKSLGLLCTNFLALYNRHGIETIGLDDAASKL---GV--ERRRIYDIVNVLESVGVLIKRAKNQYTWRG 97
                79*****************999************...**..****************************98 PP
2E2F_TDP81.29.1e-26169249171
     E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                 r+eksL+lltq+f+kl+ +se++i++l+e+ak+L+ +      +++k+RR+YDi+NVL+++nliek     ++k++++w g
  RrC7587_p1 169 RREKSLGLLTQNFIKLFVCSEARIISLDEAAKSLLGDahntsIMRTKVRRLYDIANVLSSMNLIEKthtldSRKPAFKWLG 249
                 689**************************************999************************9999*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.107.0E-262898IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467856.35E-163195IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013724.1E-283297IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.5E-203397IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.105.5E-24166250IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013726.8E-33169249IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.2E-20171249IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467854.99E-14171250IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 395 aa     Download sequence    Send to blast
MSDLPPENPK TTLSPPSSMP ESSSSLHHSY SRKQKSLGLL CTNFLALYNR HGIETIGLDD  60
AASKLGVERR RIYDIVNVLE SVGVLIKRAK NQYTWRGFSA IPAALKELQE EGGAKDTFHR  120
FYTNENVKVS DDEDDEEESC SQPHSSSPTD TSKPGSLPQS SDSSKIDNRR EKSLGLLTQN  180
FIKLFVCSEA RIISLDEAAK SLLGDAHNTS IMRTKVRRLY DIANVLSSMN LIEKTHTLDS  240
RKPAFKWLGY NGEPTFTLSS DLMHAESKKR VFGTDITNVT VKRSRTHENA TEGRMKMKQH  300
AIADSSYNQT FDDAHESRGY EFGPFAPATG GTYPTAHLED NSKRAFDVEN LVSDYRPSYQ  360
NRVLKDLFAH YMDAWKSWYS EVTQKNPLPD TSQPR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A3e-38312413228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAK3531970.0AK353197.1 Thellungiella halophila mRNA, complete cds, clone: RTFL01-26-N13.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_018439977.10.0PREDICTED: E2F transcription factor-like E2FE isoform X1
SwissprotQ8LSZ40.0E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A078JSQ70.0A0A078JSQ7_BRANA; BnaCnng63530D protein (Fragment)
STRINGBo8g076700.10.0(Brassica oleracea)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM63042743
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.20.0DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]