PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Rsa1.0_01737.1_g00003.1

Organism

Raphanus sativus

Taxonomic ID

3726

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Raphanus

Family

bHLH

Protein Properties

Length: 191aa MW: 21432.8 Da PI: 7.9964

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Rsa1.0_01737.1_g00003.1	genome	RGD	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	15.6	3e-05	1	37	16	55
HHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS HLH 16 iNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 +N+ + Lr+l P + k+ + a+i A+e+Ik++q Rsa1.0_01737.1_g00003.1 1 MNEHLKSLRSLTPCF---YIKRGDQASIIGGAIEFIKEMQ 37 8***********9...9*****************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:4.10.280.10	1.7E-5	1	48	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profile	PS50888	10.563	1	36	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamily	SSF47459	1.31E-8	1	53	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd00083	4.86E-6	1	41	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 191 aa Download sequence Send to blast
MNEHLKSLRS LTPCFYIKRG DQASIIGGAI EFIKEMQQLV QVLESKKRRK TLNRPSFPCD 60 HQTLEPSLLA AATNATTRMP FSQIENVMTT STFKEVGACS NSHHANVEAK ISGSNVVLRV 120 VSWRIEGQLV RIISVLEKLS FQVLHLNISS MEESVLYFFV VKIGLECHLS LEELTLEVQK 180 SFVPEAIVST N

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	45	49	KKRRK

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor. Together with FMA and SPCH, regulates the stomata formation. Required for the differentiation of stomatal guard cells, by promoting successive asymmetric cell divisions and the formation of guard mother cells. Promotes the conversion of the leaf epidermis into stomata. {ECO:0000269\|PubMed:17183265, ECO:0000269\|PubMed:17183267}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Rsa1.0_01737.1_g00003.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By UV, flagellin, and jasmonic acid (JA) treatments. {ECO:0000269\|PubMed:12679534}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_018488417.1	1e-133	PREDICTED: transcription factor MUTE
Swissprot	Q9M8K6	1e-118	MUTE_ARATH; Transcription factor MUTE
TrEMBL	A0A078GHS9	1e-126	A0A078GHS9_BRANA; BnaA05g31160D protein
TrEMBL	A0A397ZP52	1e-126	A0A397ZP52_BRACM; Uncharacterized protein
TrEMBL	M4DW81	1e-126	M4DW81_BRARP; Uncharacterized protein
STRING	Bra020775.1-P	1e-126	(Brassica rapa)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM7073	26	40

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G06120.1	1e-120	bHLH family protein

Publications ? help Back to Top
Casson S,Gray JE Influence of environmental factors on stomatal development. New Phytol., 2008. 178(1): p. 9-23 [PMID:18266617] Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Differentiation, 2010. 80(1): p. 1-8 [PMID:20219281] Balcerowicz M,Ranjan A,Rupprecht L,Fiene G,Hoecker U Auxin represses stomatal development in dark-grown seedlings via Aux/IAA proteins. Development, 2014. 141(16): p. 3165-76 [PMID:25063454] de Marcos A, et al. Transcriptional profiles of Arabidopsis stomataless mutants reveal developmental and physiological features of life in the absence of stomata. Front Plant Sci, 2015. 6: p. 456 [PMID:26157447] Mahoney AK, et al. Functional analysis of the Arabidopsis thaliana MUTE promoter reveals a regulatory region sufficient for stomatal-lineage expression. Planta, 2016. 243(4): p. 987-98 [PMID:26748914] Klermund C, et al. LLM-Domain B-GATA Transcription Factors Promote Stomatal Development Downstream of Light Signaling Pathways in Arabidopsis thaliana Hypocotyls. Plant Cell, 2016. 28(3): p. 646-60 [PMID:26917680] Fu ZW,Wang YL,Lu YT,Yuan TT Nitric oxide is involved in stomatal development by modulating the expression of stomatal regulator genes in Arabidopsis. Plant Sci., 2016. 252: p. 282-289 [PMID:27717464] Qi X, et al. Autocrine regulation of stomatal differentiation potential by EPF1 and ERECTA-LIKE1 ligand-receptor signaling. Elife, 2018. [PMID:28266915] Raissig MT, et al. Mobile MUTE specifies subsidiary cells to build physiologically improved grass stomata. Science, 2017. 355(6330): p. 1215-1218 [PMID:28302860] Lee JH,Jung JH,Park CM Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis. Plant Cell, 2017. 29(11): p. 2817-2830 [PMID:29070509] Han SK, et al. MUTE Directly Orchestrates Cell-State Switch and the Single Symmetric Division to Create Stomata. Dev. Cell, 2018. 45(3): p. 303-315.e5 [PMID:29738710]