PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID SMil_00001859-RA_Salv
Organism
Salvia miltiorrhiza
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Mentheae; Salvia
Family bHLH
Protein Properties Length: 495aa    MW: 55826.1 Da    PI: 4.7731
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
SMil_00001859-RA_SalvgenomeNDCTCMView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH40.93.6e-13270314655
                            HHHHHHHHHHHHHHHHHHHCTSCC.C...TTS-STCHHHHHHHHHHHHHHH CS
                    HLH   6 nerErrRRdriNsafeeLrellPk.askapskKlsKaeiLekAveYIksLq 55 
                             e+Er+RR+++N+++  Lr l+P+ +      Kl+ a+iL  A+eY+k+Lq
  SMil_00001859-RA_Salv 270 LEAERKRRKKLNDRLYALRALVPNiS------KLDRASILGDAIEYVKELQ 314
                            589*********************66......******************9 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142153.5E-158151IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088816.494264313IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000831.90E-13266316No hitNo description
SuperFamilySSF474592.88E-17267327IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000109.2E-11269314IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003531.7E-16270319IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.101.3E-16271327IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009555Biological Processpollen development
GO:0048657Biological Processanther wall tapetum cell differentiation
GO:0005634Cellular Componentnucleus
GO:0000978Molecular FunctionRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 495 aa     Download sequence    Send to blast
MLVQSFIERL RPLVGIKGWD YIVLWKLSDD RRSIELMDCC CAGGDNADEL GFEASSSTLP  60
CRDVMYPHPR LKSCDLLDLI PSSMVLDSGV HAQTLCSNQA RWLNYSHSSD SSLSSQDDIG  120
TRVLIPLSVG LVELFVNNQV GEDEGVVDLI RVQCSIFLEH QTTMSNSGTT DSFSSGQKDP  180
MSLFQQPVSS PNEKMMELPN DISIDRIHLS NGIFLEGECI FTPSMENAFH DQMQEECENN  240
RSDDSDPNDQ DEDDPKYRRR TGKGPQSKNL EAERKRRKKL NDRLYALRAL VPNISKLDRA  300
SILGDAIEYV KELQKQADDL KLELEQQSDD EGSARRTDEF PQIQQKRGPK REQESLASGY  360
HNNNNASKQK HESDQKVQQM EPQVEVYQVD GKEFFVKVFC EHKSGGFVRL VESLCAMGLE  420
VSNVNTTRHT CLASSIFKVE RKNEETVEAD DVKESLLELT RNPSGMWGGH GGAAESETNN  480
DEMHHSLCTS HHHQH
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5gnj_A9e-14262330273Transcription factor MYC2
5gnj_B9e-14262330273Transcription factor MYC2
5gnj_E9e-14262330273Transcription factor MYC2
5gnj_F9e-14262330273Transcription factor MYC2
5gnj_G9e-14262330273Transcription factor MYC2
5gnj_I9e-14262330273Transcription factor MYC2
5gnj_M9e-14262330273Transcription factor MYC2
5gnj_N9e-14262330273Transcription factor MYC2
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1257278RRRTGKGPQSKNLEAERKRRKK
2272279ERKRRKKL
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor. Plays a crucial role in tapetum development. Required for male fertility and pollen differentiation, especially during the post-meiotic transcriptional regulation of microspore development within the developing anther (PubMed:12535353). Binds E-box regions in the AHL16/TEK promoter. {ECO:0000269|PubMed:12535353, ECO:0000269|PubMed:24804694}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankKP2575240.0KP257524.1 Salvia miltiorrhiza clone 91 basic helix-loop-helix transcription factor mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011085914.10.0transcription factor ABORTED MICROSPORES
SwissprotQ9ZVX21e-119AMS_ARATH; Transcription factor ABORTED MICROSPORES
TrEMBLA0A0H3YBU70.0A0A0H3YBU7_SALMI; Basic helix-loop-helix transcription factor
STRINGVIT_01s0127g00860.t011e-153(Vitis vinifera)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA96722227
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G16910.12e-62bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Jiang J,Zhang Z,Cao J
    Pollen wall development: the associated enzymes and metabolic pathways.
    Plant Biol (Stuttg), 2013. 15(2): p. 249-63
    [PMID:23252839]
  3. Xu J, et al.
    ABORTED MICROSPORES Acts as a Master Regulator of Pollen Wall Formation in Arabidopsis.
    Plant Cell, 2014. 26(4): p. 1544-1556
    [PMID:24781116]
  4. Qian H, et al.
    Trace concentrations of imazethapyr (IM) affect floral organs development and reproduction in Arabidopsis thaliana: IM-induced inhibition of key genes regulating anther and pollen biosynthesis.
    Ecotoxicology, 2015. 24(1): p. 163-71
    [PMID:25348600]
  5. Xiong SX, et al.
    The transcription factors MS188 and AMS form a complex to activate the expression of CYP703A2 for sporopollenin biosynthesis in Arabidopsis thaliana.
    Plant J., 2016. 88(6): p. 936-946
    [PMID:27460657]
  6. Ferguson AC, et al.
    Biphasic regulation of the transcription factor ABORTED MICROSPORES (AMS) is essential for tapetum and pollen development in Arabidopsis.
    New Phytol., 2017. 213(2): p. 778-790
    [PMID:27787905]
  7. Lou Y, et al.
    Positive regulation of AMS by TDF1 and the formation of a TDF1-AMS complex are required for anther development in Arabidopsis thaliana.
    New Phytol., 2018. 217(1): p. 378-391
    [PMID:28940573]
  8. Bi H,Fan W,Zhang P
    C4 Protein of Sweet Potato Leaf Curl Virus Regulates Brassinosteroid Signaling Pathway through Interaction with AtBIN2 and Affects Male Fertility in Arabidopsis.
    Front Plant Sci, 2017. 8: p. 1689
    [PMID:29021807]