PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID SMil_00005132-RA_Salv
Organism
Salvia miltiorrhiza
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Mentheae; Salvia
Family C2H2
Protein Properties Length: 391aa    MW: 44859.1 Da    PI: 6.9923
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
SMil_00005132-RA_SalvgenomeNDCTCMView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H212.20.0005379101323
                            ET..TTTEEESSHHHHHHHHHHT CS
                zf-C2H2   3 Cp..dCgksFsrksnLkrHirtH 23 
                            C+   Cgk+F +   L++H   H
  SMil_00005132-RA_Salv  79 CSyeGCGKTFIDAGALRKHSHIH 101
                            77779**************7766 PP
2zf-C2H215.83.8e-05106130123
                            EEET..TTTEEESSHHHHHHHHHHT CS
                zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                            y+C+  +Cgk F ++s LkrH   H
  SMil_00005132-RA_Salv 106 YVCHyeNCGKKFLDSSKLKRHFLIH 130
                            9********************8877 PP
3zf-C2H217.89.3e-06184208123
                            EEET..TTTEEESSHHHHHHHHHHT CS
                zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                            + Cp  dCgk++ + + Lk+Hi +H
  SMil_00005132-RA_Salv 184 HICPyaDCGKRYAHEYKLKNHIASH 208
                            68*********************96 PP
4zf-C2H213.10.00029244269123
                            EEET..TTTEEESSHHHHHHHHHH.T CS
                zf-C2H2   1 ykCp..dCgksFsrksnLkrHirt.H 23 
                            y Cp   C k + + + L+ H+r+ H
  SMil_00005132-RA_Salv 244 YACPyeGCEKAYIHEYKLNLHLRReH 269
                            89*********************999 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:3.30.160.609.8E-1472103IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003550.003277101IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015710.78377106IPR007087Zinc finger, C2H2
SuperFamilySSF576672.55E-678102No hitNo description
PROSITE patternPS00028079101IPR007087Zinc finger, C2H2
SuperFamilySSF576677.33E-10101143No hitNo description
Gene3DG3DSA:3.30.160.606.7E-14104126IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003550.011106130IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015714.17106135IPR007087Zinc finger, C2H2
PROSITE patternPS000280108130IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.601.1E-9127145IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM0035532136178IPR015880Zinc finger, C2H2-like
Gene3DG3DSA:3.30.160.604.2E-4162181IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamilySSF576671.06E-8164210No hitNo description
Gene3DG3DSA:3.30.160.609.1E-8182208IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003550.0044184208IPR015880Zinc finger, C2H2-like
PROSITE profilePS501579.099184213IPR007087Zinc finger, C2H2
PROSITE patternPS000280186209IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.602.0E-8239267IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamilySSF576672.31E-5239267No hitNo description
SMARTSM003550.0097244269IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015710.762244274IPR007087Zinc finger, C2H2
PROSITE patternPS000280246269IPR007087Zinc finger, C2H2
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045892Biological Processnegative regulation of transcription, DNA-templated
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0043565Molecular Functionsequence-specific DNA binding
GO:0046872Molecular Functionmetal ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 391 aa     Download sequence    Send to blast
METHISHSLF DRRPISRSRG PAVKWFKEWV PQDIVSNGGK CLVLKWVNEA TLRAMKEKSK  60
EPDVVEPEPE PTTEVLFLCS YEGCGKTFID AGALRKHSHI HGERQYVCHY ENCGKKFLDS  120
SKLKRHFLIH TGERDFVCPH EGCGKVSKLA SQTSLCHGHP TQKAFSLDFN LRSHMKTHAQ  180
ENYHICPYAD CGKRYAHEYK LKNHIASHHE KANVMETPKY VMPPEKPVKT PKSTTGPASS  240
DRPYACPYEG CEKAYIHEYK LNLHLRREHP GHFPDENAKA NQPNTEHEMD EGSDQDAYAA  300
AGKRGNGKLH KQSRPKPNLK LPPSKVSHRK TSIVSPVNLN LVKKHRPLKE EIYEEEEDSE  360
ETEEERENIA ADGWRYADNN EDDDEETEYE D
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1ubd_C6e-31792138122PROTEIN (YY1 ZINC FINGER DOMAIN)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtDual-function transcription factor with both repression and activation activities. Binds to 5'-CCATATT-3' motif in target gene promoters (e.g. ABR1) (PubMed:26961720). Binds also to G-rich DNA motif 5'-GGGGGCAGTGG-3' (PubMed:22508367). Regulates the expression of genes involved in diverse cellular pathways, including glucose metabolism, photosynthesis, phototropism and stress response (e.g. salt, drought and osmotic stress) (PubMed:22508367, PubMed:26961720). Regulates plant immunity, especially during necrotrophic fungal infection (e.g. B.cinerea) (PubMed:24451981). Binds to ABR1 promoter and promotes its expression, thus negatively regulating the abscisic acid (ABA) signaling pathway. Represses ABA- and salt-responsive genes expression (PubMed:26961720). {ECO:0000269|PubMed:22508367, ECO:0000269|PubMed:24451981, ECO:0000269|PubMed:26961720}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by abscisic acid (ABA) in an ABI1- and ABI4-dependent manner. Stimulated by stress conditions including high salt, osmotic stress (e.g. mannitol) and dehydration. May be induced by ABI4 but repressed by ABR1. Repressed by darkness but induced by light. {ECO:0000269|PubMed:26961720}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_022897013.10.0zinc finger transcription factor YY1
SwissprotQ2V3L31e-143YY1_ARATH; Zinc finger transcription factor YY1
TrEMBLA0A4D9AVJ80.0A0A4D9AVJ8_SALSN; Transcription factor YY
STRINGMigut.B00804.1.p0.0(Erythranthe guttata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA73432332
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G06634.11e-139C2H2 family protein
Publications ? help Back to Top
  1. Kumekawa N,Hosouchi T,Tsuruoka H,Kotani H
    The size and sequence organization of the centromeric region of Arabidopsis thaliana chromosome 4.
    DNA Res., 2001. 8(6): p. 285-90
    [PMID:11853315]
  2. Li T,Wu XY,Li H,Song JH,Liu JY
    A Dual-Function Transcription Factor, AtYY1, Is a Novel Negative Regulator of the Arabidopsis ABA Response Network.
    Mol Plant, 2016. 9(5): p. 650-661
    [PMID:26961720]
  3. Wu XY,Li T
    A Casein Kinase II Phosphorylation Site in AtYY1 Affects Its Activity, Stability, and Function in the ABA Response.
    Front Plant Sci, 2017. 8: p. 323
    [PMID:28348572]