PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID SMil_00012109-RA_Salv
Organism
Salvia miltiorrhiza
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Mentheae; Salvia
Family bHLH
Protein Properties Length: 439aa    MW: 49604.1 Da    PI: 7.8174
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
SMil_00012109-RA_SalvgenomeNDCTCMView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH23.21.2e-071464554
                           HHHHHHHHHHHHHHHHHHHHCTSCC.C...TTS-STCHHHHHHHHHHHHHH CS
                    HLH  5 hnerErrRRdriNsafeeLrellPk.askapskKlsKaeiLekAveYIksL 54
                            +++E++RR r++   ++L +l+P   +k+ ++  s  + Le+A  YIk L
  SMil_00012109-RA_Salv 14 RKIIEKNRRIRMKGLCFKLVSLIPDhIFKTAKEFSSHLDQLEQAAAYIKIL 64
                           579**********************555777777**************976 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS508888.81964IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474592.91E-81282IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.103.1E-71380IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.0E-41464IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003530.00781570IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF1009663.66E-32295402IPR016189Translation initiation factor IF2/IF5, N-terminal
PfamPF018733.0E-37320425IPR002735Translation initiation factor IF2/IF5
SMARTSM006531.1E-63320432IPR002735Translation initiation factor IF2/IF5
Gene3DG3DSA:3.30.30.506.0E-29330381IPR016189Translation initiation factor IF2/IF5, N-terminal
SuperFamilySSF756894.58E-7399432IPR016190Translation initiation factor IF2/IF5, zinc-binding
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006413Biological Processtranslational initiation
GO:0005886Cellular Componentplasma membrane
GO:0003743Molecular Functiontranslation initiation factor activity
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 439 aa     Download sequence    Send to blast
MKRSGKSAAN KIERKIIEKN RRIRMKGLCF KLVSLIPDHI FKTAKEFSSH LDQLEQAAAY  60
IKILRGRIEE LERRKREAMM KMATNSNGLK NAANMGEISE LPILKIKDLG CDLEVLLISG  120
LKKKFTLHQI ITILEDGGAQ VVSLNLATVG DKIFHTLLAK VMITNSNQTT YTHLITIMAE  180
DENQNEVKEE VKDDGGDIAP FDPSKKKKKK KPVAQELPED DSVDTIAEKT ESLSVSDGLE  240
TSFAGLKKKK KKPAHTDLNE EKETVGEDVD DTIGEDEEGE GIVLQQNPWE GSDRDYEYEE  300
LLGRVFNILR ENNPELAGDR RRTVMRPPQV LREGTKKTVF VNFMDLCKTM HRQPEHVMTF  360
LLAEMGTSGS LDGQQRLVVK GRFAPKNFEG ILRRYINEYV ICNGCKSPDT ILSKENRLFF  420
LRCEKISHCS EVPAVTGKL
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
6k71_M8e-65267438144324Eukaryotic translation initiation factor 2 subunit 2
6k72_M8e-65267438144324Eukaryotic translation initiation factor 2 subunit 2
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1204210KKKKKKK
2245252LKKKKKKP
Functional Description ? help Back to Top
Source Description
UniProteIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011080644.11e-157eukaryotic translation initiation factor 2 subunit beta
SwissprotP558711e-122IF2B_MALDO; Eukaryotic translation initiation factor 2 subunit beta
TrEMBLA0A4D9AJC01e-164A0A4D9AJC0_SALSN; Translation initiation factor 2 subunit 2
STRINGMigut.F01768.1.p1e-156(Erythranthe guttata)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G10585.19e-09bHLH family protein