PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

SMil_00023306-RA_Salv

Organism

Salvia miltiorrhiza

Taxonomic ID

226208

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Mentheae; Salvia

Family

LSD

Protein Properties

Length: 249aa MW: 27240.2 Da PI: 8.2568

Description

LSD family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
SMil_00023306-RA_Salv	genome	NDCTCM	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-LSD1	49	9.9e-16	120	144	1	25
zf-LSD1 1 CggCrtlLsYPrGApsVRCalCdtV 25 CggCrtlL+Y+rGA+sVRC++C+tV SMil_00023306-RA_Salv 120 CGGCRTLLMYTRGATSVRCSCCHTV 144 ************************9 PP
2	zf-LSD1	46.4	6.3e-15	157	180	1	24
zf-LSD1 1 CggCrtlLsYPrGApsVRCalCdt 24 Cg+C+t+L+YP+GApsV+Ca+C+ SMil_00023306-RA_Salv 157 CGNCHTTLMYPYGAPSVKCAVCQY 180 **********************96 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF48695	5.58E-5	114	184	IPR011031	Multihaem cytochrome
TIGRFAMs	TIGR01053	3.1E-17	117	146	IPR005735	Zinc finger, LSD1-type
Gene3D	G3DSA:3.90.10.10	4.5E-4	119	182	No hit	No description
Pfam	PF06943	4.3E-13	120	144	IPR005735	Zinc finger, LSD1-type
TIGRFAMs	TIGR01053	4.6E-11	154	183	IPR005735	Zinc finger, LSD1-type
Pfam	PF06943	8.1E-14	157	181	IPR005735	Zinc finger, LSD1-type

Sequence ? help Back to Top
Protein Sequence Length: 249 aa Download sequence Send to blast
MEERERGGGV GYVAVERRGE RVSSAKVSLE AAAPLLGFFS RLRRRCVLPG QEGDEAGDAE 60 TAGKERWRRE IDGFRFQEER ERSAELKKYD DQDGIAFDYY GTIFLVHIRI FGMEMAQLIC 120 GGCRTLLMYT RGATSVRCSC CHTVNLAPAP NIAHINCGNC HTTLMYPYGA PSVKCAVCQY 180 ITNVNMGNVR VPLPMHRPIG PASPAPMPSG SSPLPNPQSQ TVVVENPMSV DKSGKLVSNV 240 VVGITTDKK

Functional Description ? help Back to Top
Source	Description
UniProt	Negative regulator of reactive oxygen-induced cell death, cold stress-induced cell death, pathogen-induced hypersensitive response (HR), basal disease resistance. May be involved in the induction of the copper/zinc superoxide dismutase CSD1 and CSD2 that detoxify accumulating superoxide before the reactive oxygen species (ROS) can trigger a cell death cascade. LSD1 and LOL1 have antagonistic effects on CSD1 and CSD2 accumulation to regulate oxidative stress-induced cell death. Antagonizes the function of BZIP10, a positive regulator of cell death, by interacting in the cytoplasm and preventing its nuclear localization. Controls lysigenous aerenchyma in hypocotyls under root hypoxia. Required for leaf acclimation in response to excess excitation energy. {ECO:0000269\|PubMed:10550898, ECO:0000269\|PubMed:11595797, ECO:0000269\|PubMed:11844114, ECO:0000269\|PubMed:12732715, ECO:0000269\|PubMed:15347794, ECO:0000269\|PubMed:16957775, ECO:0000269\|PubMed:18055613, ECO:0000269\|PubMed:18790826, ECO:0000269\|PubMed:20456049, ECO:0000269\|PubMed:21097903}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By methyl viologen. {ECO:0000269\|PubMed:20456049}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_011069944.1	3e-88	protein LSD1
Swissprot	P94077	2e-55	LSD1_ARATH; Protein LSD1
TrEMBL	A0A2G9GBS6	1e-84	A0A2G9GBS6_9LAMI; Uncharacterized protein
STRING	Migut.J01511.1.p	3e-74	(Erythranthe guttata)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA1679	24	67

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT4G20380.7	8e-55	LSD family protein

Publications ? help Back to Top
Spedaletti V, et al. Characterization of a lysine-specific histone demethylase from Arabidopsis thaliana. Biochemistry, 2008. 47(17): p. 4936-47 [PMID:18393445] Szechyńska-Hebda M,Czarnocka W,Hebda M,Bernacki MJ,Karpiński S PAD4, LSD1 and EDS1 regulate drought tolerance, plant biomass production, and cell wall properties. Plant Cell Rep., 2016. 35(3): p. 527-39 [PMID:26754794] Czarnocka W, et al. The dual role of LESION SIMULATING DISEASE 1 as a condition-dependent scaffold protein and transcription regulator. Plant Cell Environ., 2017. 40(11): p. 2644-2662 [PMID:28555890] Bernacki MJ, et al. LSD1-, EDS1- and PAD4-dependent conditional correlation among salicylic acid, hydrogen peroxide, water use efficiency and seed yield in Arabidopsis thaliana. Physiol Plant, 2019. 165(2): p. 369-382 [PMID:30461017]