PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Sme2.5_00544.1_g00012.1

Organism

Solanum melongena

Taxonomic ID

4111

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum

Family

bHLH

Protein Properties

Length: 536aa MW: 59635.4 Da PI: 8.6645

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Sme2.5_00544.1_g00012.1	genome	EGD	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	26.2	1.4e-08	41	87	3	54
HHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS HLH 3 rahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 ++h ++Er+RR+riNs +++L++l + +K +K +L++Av +k+L Sme2.5_00544.1_g00012.1 41 VTHAIAERKRRERINSHLHTLKKLFSYL-----PKKDKPRVLTEAVTQLKEL 87 68**********************9998.....6999999999999888877 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF47459	1.96E-10	30	94	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profile	PS50888	12.747	38	87	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Pfam	PF00010	5.8E-6	41	87	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd00083	2.22E-7	41	92	No hit	No description
Gene3D	G3DSA:4.10.280.10	5.6E-8	42	93	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SMART	SM00353	4.1E-5	44	93	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Gene3D	G3DSA:3.30.70.260	3.3E-6	124	190	No hit	No description
SuperFamily	SSF55021	4.35E-5	125	192	No hit	No description
CDD	cd04873	0.00205	125	189	No hit	No description
SuperFamily	SSF64356	1.19E-33	197	331	IPR011012	Longin-like domain
Gene3D	G3DSA:3.30.450.60	1.6E-40	199	331	No hit	No description
PRINTS	PR00314	1.4E-27	202	222	IPR001392	Clathrin adaptor, mu subunit
PRINTS	PR00314	1.4E-27	291	318	IPR001392	Clathrin adaptor, mu subunit
Pfam	PF00928	2.4E-37	372	502	IPR028565	Mu homology domain
SuperFamily	SSF49447	1.31E-39	372	503	IPR028565	Mu homology domain
Gene3D	G3DSA:2.60.40.1170	1.4E-39	372	507	No hit	No description
PROSITE profile	PS51072	22.012	373	536	IPR028565	Mu homology domain
PRINTS	PR00314	1.4E-27	447	474	IPR001392	Clathrin adaptor, mu subunit

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006886	Biological Process	intracellular protein transport
GO:0016192	Biological Process	vesicle-mediated transport
GO:0005802	Cellular Component	trans-Golgi network
GO:0005829	Cellular Component	cytosol
GO:0030124	Cellular Component	AP-4 adaptor complex
GO:0030131	Cellular Component	clathrin adaptor complex
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 536 aa Download sequence Send to blast
MLSSLQGCNG FFQLVEHQRK NNNGDDEKSN TKKNKSKDAA VTHAIAERKR RERINSHLHT 60 LKKLFSYLPK KDKPRVLTEA VTQLKELRKN IAQQLELSSL FIPSENDVVI ANYCDINEEQ 120 IVKTTICCED RPGLNRDLSS AIRSVQGRVI KAEMATVGGR TKAELVVVLG KANGGEKDLG 180 QLKRALKAVV ENRAVGFESS RGDSIVFRDY RGDVPKGSAE IFFRKVKFWK EDGGEEAPPV 240 FNVDGVNYFH VKVVGLLFVA TSRTNLSPSL VLELLQRIAR VIKDYLGVLN EDSLRKNFVL 300 VYELLDEVVD FGYVQTTSTE ILKSYIFNEP IMIDAGRLPP LGPAAMFMQG TKRMPGTAIT 360 KSVVANEPGG RKREEIFVDI IEKISITFSS SGYILTSEID GTIQMKSYLT GNPEIRLALN 420 EDLGIGRDGG RAAYDYGGST GSGAVILDDC NFHESVQLDS FDVDRTLTLV PPDGEFPVMN 480 YRITQEFKPP FRINTLIEEA GSLKALKKLK FVVAKCRLSK CLHVFCVNVT TPNGRE

Sequence ? help Back to Top

Protein Sequence Length: 536 aa Download sequence Send to blast

MLSSLQGCNG FFQLVEHQRK NNNGDDEKSN TKKNKSKDAA VTHAIAERKR RERINSHLHT  60
LKKLFSYLPK KDKPRVLTEA VTQLKELRKN IAQQLELSSL FIPSENDVVI ANYCDINEEQ  120
IVKTTICCED RPGLNRDLSS AIRSVQGRVI KAEMATVGGR TKAELVVVLG KANGGEKDLG  180
QLKRALKAVV ENRAVGFESS RGDSIVFRDY RGDVPKGSAE IFFRKVKFWK EDGGEEAPPV  240
FNVDGVNYFH VKVVGLLFVA TSRTNLSPSL VLELLQRIAR VIKDYLGVLN EDSLRKNFVL  300
VYELLDEVVD FGYVQTTSTE ILKSYIFNEP IMIDAGRLPP LGPAAMFMQG TKRMPGTAIT  360
KSVVANEPGG RKREEIFVDI IEKISITFSS SGYILTSEID GTIQMKSYLT GNPEIRLALN  420
EDLGIGRDGG RAAYDYGGST GSGAVILDDC NFHESVQLDS FDVDRTLTLV PPDGEFPVMN  480
YRITQEFKPP FRINTLIEEA GSLKALKKLK FVVAKCRLSK CLHVFCVNVT TPNGRE

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
4hmy_M	1e-54	201	499	12	285	AP-1 complex subunit mu-1
4p6z_M	1e-54	201	499	12	285	AP-1 complex subunit mu-1
6cm9_M	1e-54	201	499	12	285	AP-1 complex subunit mu-1
6cri_M	1e-54	201	499	11	284	AP-1 complex subunit mu-1
6cri_W	1e-54	201	499	11	284	AP-1 complex subunit mu-1
6cri_X	1e-54	201	499	11	284	AP-1 complex subunit mu-1
6d83_M	1e-54	201	499	12	285	AP-1 complex subunit mu-1
6d84_M	1e-54	201	499	12	285	AP-1 complex subunit mu-1
6d84_P	1e-54	201	499	12	285	AP-1 complex subunit mu-1
6dff_M	1e-54	201	499	12	285	AP-1 complex subunit mu-1
Search in ModeBase

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	46	51	ERKRRE

Functional Description ? help Back to Top
Source	Description
UniProt	Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. {ECO:0000250}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_004237988.1	0.0	AP-4 complex subunit mu
Swissprot	Q9SB50	0.0	AP4M_ARATH; AP-4 complex subunit mu
TrEMBL	A0A3Q7G7V3	0.0	A0A3Q7G7V3_SOLLC; Uncharacterized protein
STRING	Solyc04g076230.2.1	0.0	(Solanum lycopersicum)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA8047	2	2

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G56770.1	2e-28	bHLH family protein

Publications ? help Back to Top
Boehm M,Bonifacino JS Adaptins: the final recount. Mol. Biol. Cell, 2001. 12(10): p. 2907-20 [PMID:11598180] Thum KE,Shasha DE,Lejay LV,Coruzzi GM Light- and carbon-signaling pathways. Modeling circuits of interactions. Plant Physiol., 2003. 132(2): p. 440-52 [PMID:12805577] Thum KE,Shin MJ,Palenchar PM,Kouranov A,Coruzzi GM Genome-wide investigation of light and carbon signaling interactions in Arabidopsis. Genome Biol., 2004. 5(2): p. R10 [PMID:14759260] Happel N, et al. Arabidopsis mu A-adaptin interacts with the tyrosine motif of the vacuolar sorting receptor VSR-PS1. Plant J., 2004. 37(5): p. 678-93 [PMID:14871308] Remans T, et al. A central role for the nitrate transporter NRT2.1 in the integrated morphological and physiological responses of the root system to nitrogen limitation in Arabidopsis. Plant Physiol., 2006. 140(3): p. 909-21 [PMID:16415211] Okamoto M, et al. High-affinity nitrate transport in roots of Arabidopsis depends on expression of the NAR2-like gene AtNRT3.1. Plant Physiol., 2006. 140(3): p. 1036-46 [PMID:16415212] Li W, et al. Dissection of the AtNRT2.1:AtNRT2.2 inducible high-affinity nitrate transporter gene cluster. Plant Physiol., 2007. 143(1): p. 425-33 [PMID:17085507] Wirth J, et al. Regulation of root nitrate uptake at the NRT2.1 protein level in Arabidopsis thaliana. J. Biol. Chem., 2007. 282(32): p. 23541-52 [PMID:17573350] Girin T, et al. Identification of a 150 bp cis-acting element of the AtNRT2.1 promoter involved in the regulation of gene expression by the N and C status of the plant. Plant Cell Environ., 2007. 30(11): p. 1366-80 [PMID:17897408] Wang R,Xing X,Crawford N Nitrite acts as a transcriptome signal at micromolar concentrations in Arabidopsis roots. Plant Physiol., 2007. 145(4): p. 1735-45 [PMID:17951451] Park M, et al. Arabidopsis μ-adaptin subunit AP1M of adaptor protein complex 1 mediates late secretory and vacuolar traffic and is required for growth. Proc. Natl. Acad. Sci. U.S.A., 2013. 110(25): p. 10318-23 [PMID:23733933] Fuji K, et al. The Adaptor Complex AP-4 Regulates Vacuolar Protein Sorting at the trans-Golgi Network by Interacting with VACUOLAR SORTING RECEPTOR1. Plant Physiol., 2016. 170(1): p. 211-9 [PMID:26546666]