PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Sme2.5_00580.1_g00006.1

Organism

Solanum melongena

Taxonomic ID

4111

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum

Family

CO-like

Protein Properties

Length: 1004aa MW: 111003 Da PI: 6.7194

Description

CO-like family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Sme2.5_00580.1_g00006.1	genome	EGD	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-B_box	16.4	1.9e-05	631	671	4	38
zf-B_box 4 rkCpeHeekelqlfCedCqqllCedClleeHkg......Ht 38 r+C+++++ + +C+ ++ +lC+ C ++H H+ Sme2.5_00580.1_g00006.1 631 RVCDNCHSATCTVYCRADSAYLCAGCDAHIHAAplmasrHE 671 79*****************************6566666676 PP
2	zf-B_box	27.3	7.7e-09	673	718	3	42
zf-B_box 3 erkCpeHeekelqlfCedCqqllCedClleeHkg......Htvvpl 42 ++C+ +e+ ++ + C+ + lC++C +H+ H +vp+ Sme2.5_00580.1_g00006.1 673 VWVCEACERAPAAFLCKADAASLCASCDADIHSAnplaqrHHRVPI 718 689*****************************66899999877775 PP
3	CCT	67	5.1e-23	935	978	1	44
CCT 1 ReaallRYkeKrktRkFeKkirYesRKavAesRpRvKGrFvkqa 44 Rea++lRY+eK+k+RkFeK+irY+sRKa+Ae+RpR+KGrF+k++ Sme2.5_00580.1_g00006.1 935 REARVLRYREKKKNRKFEKTIRYASRKAYAETRPRIKGRFAKRT 978 9****************************************986 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:3.80.10.10	5.3E-40	36	193	IPR032675	Leucine-rich repeat domain, L domain-like
SuperFamily	SSF52058	6.38E-35	36	199	IPR032675	Leucine-rich repeat domain, L domain-like
Pfam	PF08263	1.5E-13	36	73	IPR013210	Leucine-rich repeat-containing N-terminal, plant-type
Pfam	PF13855	2.1E-6	124	184	IPR001611	Leucine-rich repeat
Gene3D	G3DSA:2.60.120.200	6.1E-17	228	318	IPR013320	Concanavalin A-like lectin/glucanase domain
SuperFamily	SSF56112	1.75E-76	283	575	IPR011009	Protein kinase-like domain
PROSITE profile	PS50011	35.34	305	584	IPR000719	Protein kinase domain
SMART	SM00220	9.9E-34	305	560	IPR000719	Protein kinase domain
Pfam	PF00069	5.2E-43	306	572	IPR000719	Protein kinase domain
PROSITE pattern	PS00107	0	311	333	IPR017441	Protein kinase, ATP binding site
Gene3D	G3DSA:3.30.200.20	1.1E-22	319	383	No hit	No description
Gene3D	G3DSA:1.10.510.10	3.6E-41	384	588	No hit	No description
PROSITE pattern	PS00108	0	424	436	IPR008271	Serine/threonine-protein kinase, active site
PROSITE profile	PS50119	9.727	628	675	IPR000315	B-box-type zinc finger
SMART	SM00336	0.034	628	665	IPR000315	B-box-type zinc finger
CDD	cd00021	2.16E-9	631	675	No hit	No description
SMART	SM00336	3.5E-14	671	718	IPR000315	B-box-type zinc finger
PROSITE profile	PS50119	11.049	671	718	IPR000315	B-box-type zinc finger
Pfam	PF00643	8.5E-7	672	718	IPR000315	B-box-type zinc finger
CDD	cd00021	9.25E-10	674	718	No hit	No description
Pfam	PF06203	2.9E-17	935	977	IPR010402	CCT domain
PROSITE profile	PS51017	16.638	935	977	IPR010402	CCT domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006468	Biological Process	protein phosphorylation
GO:0051607	Biological Process	defense response to virus
GO:0005622	Cellular Component	intracellular
GO:0005886	Cellular Component	plasma membrane
GO:0004672	Molecular Function	protein kinase activity
GO:0005515	Molecular Function	protein binding
GO:0005524	Molecular Function	ATP binding
GO:0008270	Molecular Function	zinc ion binding

Sequence ? help Back to Top
Protein Sequence Length: 1004 aa Download sequence Send to blast
MANRRETKAA FLYVVTFLAL WTSVAGLLSP KGVNFEVQAL VAIKSAFKDP HGVLDNWDST 60 SVDPCSWAMV TCSPESLVIG LGSPSQNLSG TLSPSIGNLT NLQIILLQNN NITGPIPKEI 120 GRLSKLQTLD LSDNFFTGDI PLSLGHLNDL KYMRLNNNSL SGEIPVSLAN MSQLTLVDLS 180 FNNLCGPVPR FPAKKFNIVG NPLICATGSE PDCYGMQLLP MSMTLNSSES SSSGKQKSHK 240 IALVFGSTLG CISLLVLGIG LFLWSRRRHN HQSFFDVKDR HHEEVSLGNL RRFQFKDLQI 300 ATNNFSSKNI LGKGGFGNVY KGYLPDGTPV AVKRLNDGNA IGGEKQFQTE VEMISLAVHR 360 NLLRLYGFCM TQSEKLLVYP YMSNGSVASR LKAKPVLDWG TRKRIAIGAA RGLLYLHEQC 420 DPKIIHRDVK AANILLDDYC EAVVGDFGLA KLLDHQDSHV TTAVRGTVGH IAPEYLSTGQ 480 SSEKTDVFGF GILLLELITG MRAIEFGKAS NQKGVMLDWV RKIHQEKKLD VLVDKDLRIN 540 YDRIELEEMV QVALLCTQYL PGHRPKMSEI VRMLEGDGLA ERWEASQKFD SSNKYKTKEL 600 SSSERFSDLT DDSLLLVQAM ELSGPSNSWA RVCDNCHSAT CTVYCRADSA YLCAGCDAHI 660 HAAPLMASRH ERVWVCEACE RAPAAFLCKA DAASLCASCD ADIHSANPLA QRHHRVPIMP 720 IPGIGASTGE GTEDDGFLSL TRDADDTTID EEDEDEAASW LLLNPPVKNN NKNNVNNNNN 780 NQNNNYGMLF GGEVVDDYLD LAEYGGDSQF NDQYSVNQQQ QHYSVPQKSY GGDSVVPVQD 840 GQRKSLILYH QQQQQQQSNH LNFQLGMEYD NSNTGYGYPA SLSHSVSISS MDVSVVPESA 900 LSETSNSHPR PPKGTIDLFS GPPIQIPPQL TPMDREARVL RYREKKKNRK FEKTIRYASR 960 KAYAETRPRI KGRFAKRTAV EAEVDQMFST QLMADSSYGI VPSF

Sequence ? help Back to Top

Protein Sequence Length: 1004 aa Download sequence Send to blast

MANRRETKAA FLYVVTFLAL WTSVAGLLSP KGVNFEVQAL VAIKSAFKDP HGVLDNWDST  60
SVDPCSWAMV TCSPESLVIG LGSPSQNLSG TLSPSIGNLT NLQIILLQNN NITGPIPKEI  120
GRLSKLQTLD LSDNFFTGDI PLSLGHLNDL KYMRLNNNSL SGEIPVSLAN MSQLTLVDLS  180
FNNLCGPVPR FPAKKFNIVG NPLICATGSE PDCYGMQLLP MSMTLNSSES SSSGKQKSHK  240
IALVFGSTLG CISLLVLGIG LFLWSRRRHN HQSFFDVKDR HHEEVSLGNL RRFQFKDLQI  300
ATNNFSSKNI LGKGGFGNVY KGYLPDGTPV AVKRLNDGNA IGGEKQFQTE VEMISLAVHR  360
NLLRLYGFCM TQSEKLLVYP YMSNGSVASR LKAKPVLDWG TRKRIAIGAA RGLLYLHEQC  420
DPKIIHRDVK AANILLDDYC EAVVGDFGLA KLLDHQDSHV TTAVRGTVGH IAPEYLSTGQ  480
SSEKTDVFGF GILLLELITG MRAIEFGKAS NQKGVMLDWV RKIHQEKKLD VLVDKDLRIN  540
YDRIELEEMV QVALLCTQYL PGHRPKMSEI VRMLEGDGLA ERWEASQKFD SSNKYKTKEL  600
SSSERFSDLT DDSLLLVQAM ELSGPSNSWA RVCDNCHSAT CTVYCRADSA YLCAGCDAHI  660
HAAPLMASRH ERVWVCEACE RAPAAFLCKA DAASLCASCD ADIHSANPLA QRHHRVPIMP  720
IPGIGASTGE GTEDDGFLSL TRDADDTTID EEDEDEAASW LLLNPPVKNN NKNNVNNNNN  780
NQNNNYGMLF GGEVVDDYLD LAEYGGDSQF NDQYSVNQQQ QHYSVPQKSY GGDSVVPVQD  840
GQRKSLILYH QQQQQQQSNH LNFQLGMEYD NSNTGYGYPA SLSHSVSISS MDVSVVPESA  900
LSETSNSHPR PPKGTIDLFS GPPIQIPPQL TPMDREARVL RYREKKKNRK FEKTIRYASR  960
KAYAETRPRI KGRFAKRTAV EAEVDQMFST QLMADSSYGI VPSF

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
3tl8_A	1e-151	266	588	1	328	BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
3tl8_D	1e-151	266	588	1	328	BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
3tl8_G	1e-151	266	588	1	328	BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
3tl8_H	1e-151	266	588	1	328	BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Involved in defense response to geminivirus and begomovirus infection via regulation of the nuclear trafficking of RPL10A. Phosphorylates RPL10A in vitro (PubMed:15489295, PubMed:18789471, PubMed:19112492, PubMed:19492062, PubMed:25707794). Activation of NIK1 downregulates cytosolic translation (PubMed:25707794). {ECO:0000269\|PubMed:15489295, ECO:0000269\|PubMed:18789471, ECO:0000269\|PubMed:19112492, ECO:0000269\|PubMed:19492062, ECO:0000269\|PubMed:25707794}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AM888389	0.0	AM888389.1 Solanum tuberosum subsp. andigena mRNA for CONSTANS protein (CO gene).

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_015066950.1	0.0	protein NSP-INTERACTING KINASE 1-like
Swissprot	Q9LFS4	0.0	NIK1_ARATH; Protein NSP-INTERACTING KINASE 1
TrEMBL	A0A3Q7F9K3	0.0	A0A3Q7F9K3_SOLLC; Uncharacterized protein
STRING	Solyc02g089550.2.1	0.0	(Solanum lycopersicum)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G02380.1	3e-92	CONSTANS-like 2

Publications ? help Back to Top
Diévart A,Clark SE Using mutant alleles to determine the structure and function of leucine-rich repeat receptor-like kinases. Curr. Opin. Plant Biol., 2003. 6(5): p. 507-16 [PMID:12972053] Fontes EP,Santos AA,Luz DF,Waclawovsky AJ,Chory J The geminivirus nuclear shuttle protein is a virulence factor that suppresses transmembrane receptor kinase activity. Genes Dev., 2004. 18(20): p. 2545-56 [PMID:15489295] Tanaka M,Takahata Y,Nakatani M Analysis of genes developmentally regulated during storage root formation of sweet potato. J. Plant Physiol., 2005. 162(1): p. 91-102 [PMID:15700424] Rocha CS,Santos AA,Machado JP,Fontes EP The ribosomal protein L10/QM-like protein is a component of the NIK-mediated antiviral signaling. Virology, 2008. 380(2): p. 165-9 [PMID:18789471] Carvalho CM, et al. Regulated nuclear trafficking of rpL10A mediated by NIK1 represents a defense strategy of plant cells against virus. PLoS Pathog., 2008. 4(12): p. e1000247 [PMID:19112492] Santos AA,Carvalho CM,Florentino LH,Ramos HJ,Fontes EP Conserved threonine residues within the A-loop of the receptor NIK differentially regulate the kinase function required for antiviral signaling. PLoS ONE, 2009. 4(6): p. e5781 [PMID:19492062] Gou X, et al. Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana. BMC Genomics, 2010. 11: p. 19 [PMID:20064227] Santos AA,Lopes KV,Apfata JA,Fontes EP NSP-interacting kinase, NIK: a transducer of plant defence signalling. J. Exp. Bot., 2010. 61(14): p. 3839-45 [PMID:20624762] Sakamoto T, et al. The tomato RLK superfamily: phylogeny and functional predictions about the role of the LRRII-RLK subfamily in antiviral defense. BMC Plant Biol., 2012. 12: p. 229 [PMID:23198823] Zorzatto C, et al. NIK1-mediated translation suppression functions as a plant antiviral immunity mechanism. Nature, 2015. 520(7549): p. 679-82 [PMID:25707794] Machado JP,Brustolini OJ,Mendes GC,Santos AA,Fontes EP NIK1, a host factor specialized in antiviral defense or a novel general regulator of plant immunity? Bioessays, 2015. 37(11): p. 1236-42 [PMID:26335701]