PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Solyc03g113760.2.1
Common NameLOC101259523
Organism
Solanum lycopersicum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum; Lycopersicon
Family E2F/DP
Protein Properties Length: 386aa    MW: 43270 Da    PI: 9.0608
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Solyc03g113760.2.1genomeITAGView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP74.11.4e-231782171
             E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                        rk+ksL+ll+++fl+l+ ++  +++ l+++a++L    v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  Solyc03g113760.2.1 17 RKQKSLGLLCSNFLSLYDRQGVETIGLDDAARRL---GV--ERRRIYDIVNVLESIGVLARKAKNRYSWKG 82
                        79*****************999************...**..****************************98 PP
2E2F_TDP74.98.3e-24152232171
             E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                         r+eksL+lltq+f+kl+ +++ ++++l+e+ak L+ +      +++k+RR+YDi+NVL++++ iek     ++k+++rw g
  Solyc03g113760.2.1 152 RREKSLGLLTQNFVKLFLCTNVDMICLDEAAKILLGDgrppaMTRTKVRRLYDIANVLSSMKYIEKthhpeTRKPAFRWLG 232
                         689**************************************99999*********************99999*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.109.8E-271384IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013724.0E-271782IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.11E-151780IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.6E-201882IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.109.0E-23148233IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.3E-31152232IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467853.26E-11154233IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023197.5E-18154232IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 386 aa     Download sequence    Send to blast
MALASDPSKE SRSTYCRKQK SLGLLCSNFL SLYDRQGVET IGLDDAARRL GVERRRIYDI  60
VNVLESIGVL ARKAKNRYSW KGLEAIPRTL EQLKEEGLKE NVSGFDGSSS AKGSDDDDDD  120
DRDSNLITSS QTDKLSSNSG VNSAAPVKSE NRREKSLGLL TQNFVKLFLC TNVDMICLDE  180
AAKILLGDGR PPAMTRTKVR RLYDIANVLS SMKYIEKTHH PETRKPAFRW LGLGGRSEYK  240
SVDAFCAIES KKRVFGTELT NTTIKRNRVA LPMDGISDEA TRKQLLTEVK CENLENAFHI  300
PKQEPGLTAS KKSYHFGPFA PPTVPQAEVS EADRMKRVHD WESLASSYRP QYHNQALKDL  360
FAHYVEAWKS WYLEVAGKNP IQLIS*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A2e-36172244228Transcription factor E2F8
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected during early S phase. Expressed at both the G1/S and S/G2 transitions, with a peak during G2. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:18787127}.
UniprotTISSUE SPECIFICITY: Expressed exclusively in mitotically dividing cells. Highly expressed in young leaves and mature flowers. Lower expression in young stalk and in young and mature flowers. {ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366}.
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapSolyc03g113760.2.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_004236152.10.0E2F transcription factor-like E2FE
SwissprotQ8LSZ41e-123E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A3Q7FQY60.0A0A3Q7FQY6_SOLLC; Uncharacterized protein
STRINGSolyc03g113760.2.10.0(Solanum lycopersicum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA25222457
Representative plantOGRP24741634
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-123DP-E2F-like 1
Publications ? help Back to Top
  1. Wang Y,van der Hoeven RS,Nielsen R,Mueller LA,Tanksley SD
    Characteristics of the tomato nuclear genome as determined by sequencing undermethylated EcoRI digested fragments.
    Theor. Appl. Genet., 2005. 112(1): p. 72-84
    [PMID:16208505]
  2. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  3. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  4. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]