PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Sp_210010_gnpu.t1

Common Name

SOVF_210010

Organism

Spinacia oleracea

Taxonomic ID

3562

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Caryophyllales; Chenopodiaceae; Chenopodioideae; Anserineae; Spinacia

Family

E2F/DP

Protein Properties

Length: 460aa MW: 51030.1 Da PI: 4.6201

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Sp_210010_gnpu.t1	genome	TBVR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	78.7	5.6e-25	134	201	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l+e++++gi++l+e a++L e + ++RRiYDi+NVLe+++liek kn i+wkg Sp_210010_gnpu.t1 134 RSGRSLVLLTKKFINLIEQAKDGILDLKETAQTL--EVQNRQKRRIYDITNVLEGIGLIEK-LKNGIQWKG 201 6789****************************..544459***************.*****98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	7.9E-24	132	203	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	6.5E-28	134	201	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	1.1E-20	136	201	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	1.01E-13	137	202	IPR011991	Winged helix-turn-helix DNA-binding domain
CDD	cd14660	9.23E-43	214	318	No hit	No description
SuperFamily	SSF144074	3.66E-31	215	318	No hit	No description
Pfam	PF16421	9.5E-31	217	316	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0005667	Cellular Component	transcription factor complex
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 460 aa Download sequence Send to blast
MTTPSASNDR QQAAPQKREV VLLARMKPPF AASPGEYYSF SDHRAPHLPI PDSIVVKTPP 60 KKRKNKPADH NTESTYRTIS QGCREVDNSS FQTPISGKGG KGQRASRDTS CDIVHPQTPL 120 SIVGSPVENL TPSRSGRSLV LLTKKFINLI EQAKDGILDL KETAQTLEVQ NRQKRRIYDI 180 TNVLEGIGLI EKLKNGIQWK GPNVSRPGEV DHGVASLQED IENLSMEERN LDDRIREIQE 240 RLRGITEDNN NQKWLFVSEE DMKALPCFQD ETLIAIKAPH GTTLEVPEPD EAVDYPQRRY 300 RIVLRSTMGP IDVYLVSQFE EKVEETNGAE TIQSLPSTSG CDNLPNDMAE NESNLNKIEL 360 NGQEAHRMSS DGNAPQDLSG IMKILPEVYN DADYWLLSDA DVSITDMWGA ESGVDWDELG 420 IVPEDYAVGD IHTQQQPQGP LSLSPCAAVV IPAIVDSTGR

Sequence ? help Back to Top

Protein Sequence Length: 460 aa Download sequence Send to blast

MTTPSASNDR QQAAPQKREV VLLARMKPPF AASPGEYYSF SDHRAPHLPI PDSIVVKTPP  60
KKRKNKPADH NTESTYRTIS QGCREVDNSS FQTPISGKGG KGQRASRDTS CDIVHPQTPL  120
SIVGSPVENL TPSRSGRSLV LLTKKFINLI EQAKDGILDL KETAQTLEVQ NRQKRRIYDI  180
TNVLEGIGLI EKLKNGIQWK GPNVSRPGEV DHGVASLQED IENLSMEERN LDDRIREIQE  240
RLRGITEDNN NQKWLFVSEE DMKALPCFQD ETLIAIKAPH GTTLEVPEPD EAVDYPQRRY  300
RIVLRSTMGP IDVYLVSQFE EKVEETNGAE TIQSLPSTSG CDNLPNDMAE NESNLNKIEL  360
NGQEAHRMSS DGNAPQDLSG IMKILPEVYN DADYWLLSDA DVSITDMWGA ESGVDWDELG  420
IVPEDYAVGD IHTQQQPQGP LSLSPCAAVV IPAIVDSTGR

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	2e-23	131	201	4	73	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_021836677.1	0.0	transcription factor E2FB-like
Swissprot	Q9FV71	1e-116	E2FB_ARATH; Transcription factor E2FB
TrEMBL	A0A0K9QA03	0.0	A0A0K9QA03_SPIOL; Uncharacterized protein
STRING	XP_010685422.1	0.0	(Beta vulgaris)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G22220.2	1e-116	E2F transcription factor 1

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]