PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Spipo2G0120300
Organism
Spirodela polyrhiza
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Alismatales; Araceae; Lemnoideae; Spirodela
Family E2F/DP
Protein Properties Length: 475aa    MW: 52359.5 Da    PI: 4.8316
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Spipo2G0120300genomeMIPS/IBISView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP85.44.3e-27145210171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                     r+++sL+llt+kf++ll+++e+gi++ln++a++L    v  ++RRiYDi+NVLe+++liekk kn+irwkg
  Spipo2G0120300 145 RYDSSLGLLTKKFINLLKHAEDGILDLNKAAETL---RV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 210
                     6899******************************...88..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.107.5E-29143212IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467855.98E-17145208IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.6E-34145210IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.4E-24147210IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146602.76E-47221327No hitNo description
SuperFamilySSF1440748.89E-33222327No hitNo description
PfamPF164214.8E-32226325IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 475 aa     Download sequence    Send to blast
MSSGGSRAVT NHRSGQPPGQ ILQPLKRHLP FLSTRPPFVS PDDYHRFSTA ENSQITEEAT  60
EAIVVRTPLK RKPDYDEGEV AESGDWATSP GNMVNSPLQT PVSGKRDKAF GRSKSVKNVR  120
SLPQTPVSND GSPSSNAVTP VGTCRYDSSL GLLTKKFINL LKHAEDGILD LNKAAETLRV  180
QKRRIYDITN VLEGIGLIEK KLKNRIRWKG LDVSRPGDVD EDLASLQAEV KNLSIEERQL  240
DDQISEMRDR LRGLSEDENH QKWLYVTEED IKGVPSFQNE TLIAIKAPHG TTLEVPDPDE  300
AVDYPQRRYR IVLRSTMGPI DVYLVSQFEE KFEEMGSMEI AGGAHPVSSL PPVEQRGMMI  360
SDENRAQEPD FSIAQDPQQL CADNPSTSQD FSGGMTRIVP SNMDTDADYW LVINSGVSIT  420
DMWRTEQPPP WDEIGRLTAD DFLLSNVSSP RPQSPRSGGA AEGAPPGATS LGRT*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A4e-24140211174PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_017700050.10.0transcription factor E2FB-like
SwissprotQ9FNY01e-138E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A1D1Z0090.0A0A1D1Z009_9ARAE; Transcription factor E2FA (Fragment)
STRINGXP_010246568.10.0(Nelumbo nucifera)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MonocotsOGMP62537148
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-141E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]