PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Thecc1EG011971t3
Common NameTCM_011971
Organism
Theobroma cacao
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Byttnerioideae; Theobroma
Family E2F/DP
Protein Properties Length: 385aa    MW: 42938.1 Da    PI: 9.0247
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Thecc1EG011971t3genomeCGDView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP70.61.8e-222186171
           E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                      rk+ksL+ll+++fl+l+++++ + + l+e+a +L    v  +r RiYDi+NVLe+++++++k+kn+++wkg
  Thecc1EG011971t3 21 RKQKSLGLLCSNFLSLYNREDVELIGLDEAAAKL---GV--ERHRIYDIVNVLESVGVLTRKAKNKYTWKG 86
                      79*****************999************...**..****************************98 PP
2E2F_TDP77.11.8e-24159239171
           E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                       r+eksL+lltq+f+kl+ +s+++ ++l+e+a+ L+ +      +++k+RR+YDi+NVL+++nliek     ++k+++rw g
  Thecc1EG011971t3 159 RREKSLGLLTQNFVKLFVCSNAELISLDEAARLLLGNahntsIMRTKVRRLYDIANVLSSMNLIEKthtvdTRKPAFRWLG 239
                       689*******************************9999***999***********************************87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.104.5E-251787IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467854.41E-152084IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013726.6E-272186IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023198.4E-202286IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.102.0E-23156240IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.4E-31159239IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467857.48E-14161240IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023198.4E-20161239IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 385 aa     Download sequence    Send to blast
MPVSSSPSLP ESSSRHYTYS RKQKSLGLLC SNFLSLYNRE DVELIGLDEA AAKLGVERHR  60
IYDIVNVLES VGVLTRKAKN KYTWKGFAAI PKALQDLKEE GFSSNFKNLD ANNNAKVSDD  120
DDDDEDDEGF SNPNTGSQTE TSKPTSVLKS SASSKIDNRR EKSLGLLTQN FVKLFVCSNA  180
ELISLDEAAR LLLGNAHNTS IMRTKVRRLY DIANVLSSMN LIEKTHTVDT RKPAFRWLGL  240
SGKSDKGSAD ALVLHESRKR AFGTDVTNII SKRNKVDSSN EGNVKQCMKM QKQIKVENLV  300
AVADRRSWED SKQGSKSYQF GPFAPVNLSR SGNSENNVKR VHDWESLAST YRPQYQLHGS  360
VEIMVHGSCW EEANTTNFLM RQAE*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A3e-39202313228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_017973123.10.0PREDICTED: E2F transcription factor-like E2FE isoform X1
SwissprotQ8LSZ41e-129E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A061FU250.0A0A061FU25_THECC; DP-E2F-like 1 isoform 3
STRINGEOY205910.0(Theobroma cacao)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.11e-134DP-E2F-like 1
Publications ? help Back to Top
  1. Motamayor JC, et al.
    The genome sequence of the most widely cultivated cacao type and its use to identify candidate genes regulating pod color.
    Genome Biol., 2013. 14(6): p. r53
    [PMID:23731509]
  2. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  3. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  4. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]