PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Thecc1EG017926t1
Common NameTCM_017926
Organism
Theobroma cacao
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Byttnerioideae; Theobroma
Family E2F/DP
Protein Properties Length: 555aa    MW: 62932.6 Da    PI: 10.0654
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Thecc1EG017926t1genomeCGDView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP74.31.2e-231984171
           E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                      rkeksL+ll+++fl+l+++ + +++ l+++a++L    v  +rRRiYD++N+Le+++++++k kn+++wkg
  Thecc1EG017926t1 19 RKEKSLGLLCSNFLALYNHDSIQTIGLDDAASKL---GV--ERRRIYDVVNILESIGVVARKGKNQYSWKG 84
                      79*****************999************...**..****************************98 PP
2E2F_TDP51.51.7e-16183254871
           E2F_TDP   8 lltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                       +l+ ++  l++  +++i+tl+++a +L+ +      +++k+RR+YDi+NV++++nliek     ++k+++rw g
  Thecc1EG017926t1 183 VLSGEY--LISFLQAEIITLDSAAVALLGDvhnstAMRTKVRRLYDIANVFSSMNLIEKthhpeSRKPAFRWLG 254
                       556563..34445789*******************************************9999999******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.104.3E-251785IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.4E-291984IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.45E-151982IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023193.1E-202084IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.104.9E-18143255IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.2E-23145254IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023198.9E-16147254IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467854.49E-9181255IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 555 aa     Download sequence    Send to blast
MSSFLSRESE PNSRTFYCRK EKSLGLLCSN FLALYNHDSI QTIGLDDAAS KLGVERRRIY  60
DVVNILESIG VVARKGKNQY SWKGFGEIPR ALEKLKEEAL KENFYISGCN KSLRVLDENG  120
SRGSFNLKID GQDNPSESSK HIDTKREKSL WLITQNFVKL FLCSDVRQLL FNVGLWFMNC  180
LLVLSGEYLI SFLQAEIITL DSAAVALLGD VHNSTAMRTK VRRLYDIANV FSSMNLIEKT  240
HHPESRKPAF RWLGWGAKLR NGSMTALALN ESKKRMFGTE ITNHSLKRMK ANSSVHRKLN  300
QKENMAMHIK HECVENDNKM KQHLKQSSRG FVFGPFTPGG MPTGNKNKRP VGDWESLAST  360
YKPQYLNQVH GDWTRKKRLK FLVIRFDKIT HQSQCLPSEH NGICYRILLV TSLLITWKHG  420
SLGMQKLLEK EKLILVPDPL LCFSNSRSPN TPVQNGKQTF FTGQHAVHIH RLDSIPKTAK  480
LRGGSSRFIS GLYPNPIDVE FLNCADIVVA KSQVLWCSSL CRETMRATCD PLVPCPNFEK  540
RDFTETTNNG PTIV*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A2e-29192464228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Does not bind retinoblastoma-related proteins. Acts as a growth regulator but is not associated with changes in the expression of cell cycle marker genes or in nuclear ploidy levels. Has no effect on cell proliferation, but may repress cell wall biosynthesis genes during cell elongation in differentiated cells. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15308755}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021297822.10.0E2F transcription factor-like E2FF isoform X1
SwissprotQ8RWL01e-103E2FF_ARATH; E2F transcription factor-like E2FF
TrEMBLA0A061ELS40.0A0A061ELS4_THECC; DP-E2F-like 1, putative
STRINGEOY032390.0(Theobroma cacao)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM60032547
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G01330.11e-89DP-E2F-like protein 3
Publications ? help Back to Top
  1. Dohmann EM, et al.
    The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability.
    Development, 2008. 135(11): p. 2013-22
    [PMID:18434413]
  2. Motamayor JC, et al.
    The genome sequence of the most widely cultivated cacao type and its use to identify candidate genes regulating pod color.
    Genome Biol., 2013. 14(6): p. r53
    [PMID:23731509]