PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Thhalv10023433m
Common NameEUTSA_v10023356mg
Organism
Eutrema salsugineum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Eutremeae; Eutrema
Family bHLH
Protein Properties Length: 483aa    MW: 53969.8 Da    PI: 4.8972
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Thhalv10023433mgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH45.91e-14292338455
                      HHHHHHHHHHHHHHHHHHHHHCTSCC.C...TTS-STCHHHHHHHHHHHHHHH CS
              HLH   4 ahnerErrRRdriNsafeeLrellPk.askapskKlsKaeiLekAveYIksLq 55 
                      +h   Er+RR+++N++f +Lr+++P+ +      K +K++iL  ++eY+++Lq
  Thhalv10023433m 292 NHAFSERKRREKLNDRFMTLRSIIPSiS------KIDKVSILDDTIEYLQELQ 338
                      78889*********************66......******************9 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142151.5E-24181IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088816.749288337IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474593.01E-19290358IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.102.4E-18292356IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000838.43E-16292342No hitNo description
PfamPF000104.2E-12292338IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003531.3E-16294343IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009957Biological Processepidermal cell fate specification
GO:0005634Cellular Componentnucleus
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 483 aa     Download sequence    Send to blast
MSFVFNIGEG IPGGALSNGE PIWLCNAHTA DNKVFTRSLL AKSASLQTVV CFPFLGGVLE  60
IGTTEHITED LNVIQCVKTL FLEAPPFATI STRSDFQEIF DPLCDDKYIP VFGNETFPTT  120
STSGFEQEPE DHDSFINGGG ASQVQSWQFV GEELSNCVHQ SLNSSDCVSQ TFVGTTRRVA  180
CDPRKSKVQR LGQIQEQSNH VNMDDDVHYQ SVISTIFKTT HQLILGPQFQ NFDKRSSFTR  240
WKRSSSAETL GEKSQKMLKK IIFEVPLMNQ KALLLPDTPE DSEFKVGDET ANHAFSERKR  300
REKLNDRFMT LRSIIPSISK IDKVSILDDT IEYLQELQRR VQELESCRES TNTEIRIAMK  360
RKKPEDEDER ASANCMNSKR KESDVNVGED EPADTGYAGL TDNLRIGSFG NEVVIELRCA  420
WREGILLEIM DVISDLNLDS HSVQSSTGDG LLCLTVNCKH KGTKIATTGM IQEALQRVAW  480
IC*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5gnj_A4e-13288346462Transcription factor MYC2
5gnj_B4e-13288346462Transcription factor MYC2
5gnj_E4e-13288346462Transcription factor MYC2
5gnj_F4e-13288346462Transcription factor MYC2
5gnj_G4e-13288346462Transcription factor MYC2
5gnj_I4e-13288346462Transcription factor MYC2
5gnj_M4e-13288346462Transcription factor MYC2
5gnj_N4e-13288346462Transcription factor MYC2
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1296301ERKRRE
2297302RKRREK
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator, when associated with MYB75/PAP1, MYB90/PAP2 or TT2. Involved in epidermal cell fate specification. Regulates negatively stomata formation but promotes trichome formation. Together with MYB66/WER, promotes the formation of non-hair cells in root epidermis cells in the N position. Whereas together with CPC, promotes the formation of hair cells in root epidermis cells in the H position by inhibiting non-hair cell formation. Seems also to play a role in the activation of anthocyanin biosynthesis, probably together with MYB75/PAP1. Involved in seed mucilage production. Activates the transcription of GL2. {ECO:0000269|PubMed:12917293, ECO:0000269|PubMed:12956536, ECO:0000269|PubMed:14627722, ECO:0000269|PubMed:15361138, ECO:0000269|PubMed:15590742}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapThhalv10023433m
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By UV treatment. Negatively regulated by MYB66/WER, GL3 and BHLH2 in the developing non-hair cells, and positively regulated by CPC and TRY in the developing hair cells. {ECO:0000269|PubMed:12679534, ECO:0000269|PubMed:15590742}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAK3532170.0AK353217.1 Thellungiella halophila mRNA, complete cds, clone: RTFL01-32-J06.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006391734.10.0transcription factor EGL1
SwissprotQ9CAD00.0EGL1_ARATH; Transcription factor EGL1
TrEMBLE4MXH00.0E4MXH0_EUTHA; mRNA, clone: RTFL01-32-J06
TrEMBLV4JUJ60.0V4JUJ6_EUTSA; Uncharacterized protein
STRINGXP_006391734.10.0(Eutrema salsugineum)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G63650.30.0bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Liu Z,Shi MZ,Xie DY
    Regulation of anthocyanin biosynthesis in Arabidopsis thaliana red pap1-D cells metabolically programmed by auxins.
    Planta, 2014. 239(4): p. 765-81
    [PMID:24370633]
  3. Nayidu NK, et al.
    Comparison of five major trichome regulatory genes in Brassica villosa with orthologues within the Brassicaceae.
    PLoS ONE, 2014. 9(4): p. e95877
    [PMID:24755905]
  4. Cheng Y, et al.
    Brassinosteroids control root epidermal cell fate via direct regulation of a MYB-bHLH-WD40 complex by GSK3-like kinases.
    Elife, 2018.
    [PMID:24771765]
  5. Ranocha P,Francoz E,Burlat V,Dunand C
    Expression of PRX36, PMEI6 and SBT1.7 is controlled by complex transcription factor regulatory networks for proper seed coat mucilage extrusion.
    Plant Signal Behav, 2014. 9(11): p. e977734
    [PMID:25531128]
  6. Nemie-Feyissa D,Heidari B,Blaise M,Lillo C
    Analysis of interactions between heterologously produced bHLH and MYB proteins that regulate anthocyanin biosynthesis: quantitative interaction kinetics by Microscale Thermophoresis.
    Phytochemistry, 2015. 111: p. 21-6
    [PMID:25659750]
  7. Kwak SH,Song SK,Lee MM,Schiefelbein J
    TORNADO1 regulates root epidermal patterning through the WEREWOLF pathway in Arabidopsis thaliana.
    Plant Signal Behav, 2015. 10(12): p. e1103407
    [PMID:26451798]
  8. Dai X, et al.
    A single amino acid substitution in the R3 domain of GLABRA1 leads to inhibition of trichome formation in Arabidopsis without affecting its interaction with GLABRA3.
    Plant Cell Environ., 2016. 39(4): p. 897-907
    [PMID:26667588]
  9. Friede A, et al.
    The Second Intron Is Essential for the Transcriptional Control of the Arabidopsis thaliana GLABRA3 Gene in Leaves.
    Front Plant Sci, 2017. 8: p. 1382
    [PMID:28848584]
  10. Feng K, et al.
    An R2R3-MYB transcription factor, OjMYB1, functions in anthocyanin biosynthesis in Oenanthe javanica.
    Planta, 2018. 247(2): p. 301-315
    [PMID:28965159]
  11. Wen J, et al.
    The C-terminal domains of Arabidopsis GL3/EGL3/TT8 interact with JAZ proteins and mediate dimeric interactions.
    Plant Signal Behav, 2018. 13(1): p. e1422460
    [PMID:29293407]