PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Traes_3DL_8407DBC44.1

Organism

Triticum aestivum

Taxonomic ID

4565

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; BOP clade; Pooideae; Triticodae; Triticeae; Triticinae; Triticum

Family

C2H2

Protein Properties

Length: 111aa MW: 12201.1 Da PI: 8.9581

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Traes_3DL_8407DBC44.1	genome	IWGSC	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	12.5	0.00044	68	83	4	19
TTTTEEESSHHHHHHH CS zf-C2H2 4 pdCgksFsrksnLkrH 19 + Cgk+F+ + Lk+H Traes_3DL_8407DBC44.1 68 HGCGKTFPGPKALKNH 83 68************** PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF56672	1.05E-7	7	60	No hit	No description
Gene3D	G3DSA:1.10.150.20	1.2E-8	9	61	No hit	No description

Sequence ? help Back to Top
Protein Sequence Length: 111 aa Download sequence Send to blast
MLCRKQLGGK LGSSLQDDLG VKTVGDLLGF TEEKLQEYYG VNTGTWLWKT ARGFSGEEVE 60 DRLLPKSHGC GKTFPGPKAL KNHSSVRMLA ACYAFCSRTT FPTLELPIKT S

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
3mr6_A	8e-18	5	87	259	341	DNA polymerase eta
3tq1_A	8e-18	5	87	259	341	DNA polymerase eta
4eey_A	8e-18	5	87	259	341	DNA polymerase eta
6d0m_A	8e-18	5	87	259	341	DNA polymerase eta
6d0z_A	8e-18	5	87	259	341	DNA polymerase eta
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Functional Description ? help Back to Top
Source	Description
UniProt	Error-free DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis (TLS), where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers and confers resistance to ultraviolet light. Depending on the context, it inserts the correct base, but may cause base transitions and transversions. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci. Exhibits cyclobutane dimer nonmutagenic bypass activity in vitro. {ECO:0000269\|PubMed:16857217, ECO:0000269\|PubMed:18339443, ECO:0000269\|PubMed:18366182, ECO:0000269\|PubMed:18494853, ECO:0000269\|PubMed:21030509, ECO:0000269\|PubMed:21455019, ECO:0000269\|PubMed:22018494}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AK365838	1e-106	AK365838.1 Hordeum vulgare subsp. vulgare mRNA for predicted protein, complete cds, clone: NIASHv2038C17.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_020168934.1	2e-50	DNA polymerase eta isoform X2
Swissprot	Q8H2D5	1e-38	POLH_ARATH; DNA polymerase eta
TrEMBL	A0A453FJI0	1e-54	A0A453FJI0_AEGTS; Uncharacterized protein
STRING	Traes_3DL_8407DBC44.1	4e-77	(Triticum aestivum)

Publications ? help Back to Top
Kunz BA,Anderson HJ,Osmond MJ,Vonarx EJ Components of nucleotide excision repair and DNA damage tolerance in Arabidopsis thaliana. Environ. Mol. Mutagen., 2005 Mar-Apr. 45(2-3): p. 115-27 [PMID:15645454] Takahashi S, et al. Roles of Arabidopsis AtREV1 and AtREV7 in translesion synthesis. Plant Physiol., 2005. 138(2): p. 870-81 [PMID:15908599] Santiago MJ,Alejandre-Durán E,Ruiz-Rubio M Analysis of UV-induced mutation spectra in Escherichia coli by DNA polymerase eta from Arabidopsis thaliana. Mutat. Res., 2006. 601(1-2): p. 51-60 [PMID:16857217] Santiago MJ,Ruiz-Rubio M,Dio LD,González-Reyes JA,Alejandre-Durán E Ubiquitous expression of two translesion synthesis DNA polymerase genes in Arabidopsis. Planta, 2008. 227(6): p. 1269-77 [PMID:18270731] Hoffman PD,Curtis MJ,Iwai S,Hays JB Biochemical evolution of DNA polymerase eta: properties of plant, human, and yeast proteins. Biochemistry, 2008. 47(16): p. 4583-96 [PMID:18366182] Anderson HJ, et al. Arabidopsis thaliana Y-family DNA polymerase eta catalyses translesion synthesis and interacts functionally with PCNA2. Plant J., 2008. 55(6): p. 895-908 [PMID:18494853] Curtis MJ, et al. Reciprocal chromosome translocation associated with TDNA-insertion mutation in Arabidopsis: genetic and cytological analyses of consequences for gametophyte development and for construction of doubly mutant lines. Planta, 2009. 229(4): p. 731-45 [PMID:19082841] Kunz BA A role for PCNA2 in translesion synthesis by Arabidopsis thaliana DNA polymerase eta. Plant Signal Behav, 2008. 3(10): p. 897-8 [PMID:19704534] Nakagawa M,Takahashi S,Tanaka A,Narumi I,Sakamoto AN Role of AtPolζ, AtRev1, and AtPolη in UV light-induced mutagenesis in Arabidopsis. Plant Physiol., 2011. 155(1): p. 414-20 [PMID:21030509] Nakagawa M,Takahashi S,Narumi I,Sakamoto AN Role of AtPolζ, AtRev1 and AtPolη in γ ray-induced mutagenesis. Plant Signal Behav, 2011. 6(5): p. 728-31 [PMID:21455019] Curtis MJ,Hays JB Cooperative responses of DNA-damage-activated protein kinases ATR and ATM and DNA translesion polymerases to replication-blocking DNA damage in a stem-cell niche. DNA Repair (Amst.), 2011. 10(12): p. 1272-81 [PMID:22018494] Brenchley R, et al. Analysis of the bread wheat genome using whole-genome shotgun sequencing. Nature, 2012. 491(7426): p. 705-10 [PMID:23192148]