PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

WALNUT_00006670-RA

Organism

Juglans regia

Taxonomic ID

51240

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fagales; Juglandaceae; Juglans

Family

E2F/DP

Protein Properties

Length: 472aa MW: 52555.5 Da PI: 4.6619

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
WALNUT_00006670-RA	genome	JHU	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	74.6	1e-23	134	193	7	71
E2F_TDP 7 rlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 +llt++f++ll+++e+gi++ln++a +L +v ++RRiYDi+NVLe++++iekk kn+i+wkg WALNUT_00006670-RA 134 GLLTKRFINLLKQAEDGILDLNKAAGAL---EV--QKRRIYDITNVLEGIGIIEKKLKNRIHWKG 193 68************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	1.1E-24	127	195	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	9.4E-29	128	193	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	1.77E-14	133	194	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	3.1E-21	134	193	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	1.02E-42	204	310	No hit	No description
SuperFamily	SSF144074	1.57E-30	206	310	No hit	No description
Pfam	PF16421	3.7E-30	209	308	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 472 aa Download sequence Send to blast
MSGGARPPNC PEPPLTGSIQ FPTPPPKRNL AALASTKPPF LLPDDYYCFF SSVDSHRAAD 60 HEAEAIVVRS PQLKRNSGTD ENEVQSAEWA TGPGYTCVVN SILNTPVSIK EGRIYNRPKS 120 SKGNRVTKRE NFTGLLTKRF INLLKQAEDG ILDLNKAAGA LEVQKRRIYD ITNVLEGIGI 180 IEKKLKNRIH WKGLDASRPG VVEDDASELQ AELENLFMQE QSLDDQIRVM RERLRDLSED 240 ENNQKWLFVT KEDIKGIPCL QNETLLAIKA PHGTTLEAPD PDEAVDYTQR RYRIILRSTV 300 APIDVYLVSQ FEEKFEEMNG AEPPVSFPVA SCSVVNAEST LTLQAQPNHH MCYDINASQD 360 FVGGMMKIVP SDVDNDADYW LLSDAEVSIT DMWKTDGIPL RSTFSQFFPH VVLYLTLWML 420 NSLTPTMAAV ESTGMDVLHT DFGIADVCTP IPETPLSGIT EVPSMAVNST QR

Sequence ? help Back to Top

Protein Sequence Length: 472 aa Download sequence Send to blast

MSGGARPPNC PEPPLTGSIQ FPTPPPKRNL AALASTKPPF LLPDDYYCFF SSVDSHRAAD  60
HEAEAIVVRS PQLKRNSGTD ENEVQSAEWA TGPGYTCVVN SILNTPVSIK EGRIYNRPKS  120
SKGNRVTKRE NFTGLLTKRF INLLKQAEDG ILDLNKAAGA LEVQKRRIYD ITNVLEGIGI  180
IEKKLKNRIH WKGLDASRPG VVEDDASELQ AELENLFMQE QSLDDQIRVM RERLRDLSED  240
ENNQKWLFVT KEDIKGIPCL QNETLLAIKA PHGTTLEAPD PDEAVDYTQR RYRIILRSTV  300
APIDVYLVSQ FEEKFEEMNG AEPPVSFPVA SCSVVNAEST LTLQAQPNHH MCYDINASQD  360
FVGGMMKIVP SDVDNDADYW LLSDAEVSIT DMWKTDGIPL RSTFSQFFPH VVLYLTLWML  420
NSLTPTMAAV ESTGMDVLHT DFGIADVCTP IPETPLSGIT EVPSMAVNST QR

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	1e-20	127	194	6	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_018851226.1	0.0	PREDICTED: transcription factor E2FA-like isoform X1
Swissprot	Q9FNY0	1e-130	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A2I4H4Z0	0.0	A0A2I4H4Z0_JUGRE; transcription factor E2FA-like isoform X1
STRING	VIT_08s0007g02510.t01	0.0	(Vitis vinifera)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF1947	34	90

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-134	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]