PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_009591846.1
Organism
Nicotiana tomentosiformis
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family HD-ZIP
Protein Properties Length: 374aa    MW: 42640.4 Da    PI: 4.982
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_009591846.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox54.81.6e-171770457
                    -SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHHC CS
        Homeobox  4 RttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakekk 57
                    + ++++eq++ Le+ F +++++  e++ +L+++lg++ rq+++W+qNrRa++k+
  XP_009591846.1 17 KKRLNQEQIKLLESSFDSTKKLEPEKKLQLSRELGVPPRQISIWYQNRRARWKN 70
                    56799***********************************************95 PP
2HD-ZIP_I/II101.47.7e-3316107293
     HD-ZIP_I/II   2 kkrrlskeqvklLEesFeeeekLeperKvelareLglqprqvavWFqnrRARtktkqlEkdyeaLkraydalkeenerLekeveeLreelke 93 
                     +k+rl++eq+klLE+sF++++kLepe+K +l+reLg+ prq+ +W+qnrRAR+k+++lE dy+aL+ ++++  +e+ +Leke+e+Lr el++
  XP_009591846.1  16 NKKRLNQEQIKLLESSFDSTKKLEPEKKLQLSRELGVPPRQISIWYQNRRARWKNQNLEIDYNALQLKLETALSEKLQLEKETERLRGELQK 107
                     79*************************************************************************************99986 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5007115.6451171IPR001356Homeobox domain
SMARTSM003893.6E-151375IPR001356Homeobox domain
SuperFamilySSF466896.68E-171480IPR009057Homeodomain-like
CDDcd000867.30E-141772No hitNo description
PfamPF000466.3E-151770IPR001356Homeobox domain
Gene3DG3DSA:1.10.10.603.6E-191878IPR009057Homeodomain-like
PROSITE patternPS0002704669IPR017970Homeobox, conserved site
PfamPF117891.2E-13267329IPR004181Zinc finger, MIZ-type
Gene3DG3DSA:3.30.40.108.6E-6282329IPR013083Zinc finger, RING/FYVE/PHD-type
SuperFamilySSF578502.08E-6282330No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0006974Biological Processcellular response to DNA damage stimulus
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0010082Biological Processregulation of root meristem growth
GO:0016925Biological Processprotein sumoylation
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0045931Biological Processpositive regulation of mitotic cell cycle
GO:0060250Biological Processgerm-line stem-cell niche homeostasis
GO:0080038Biological Processpositive regulation of cytokinin-activated signaling pathway
GO:0005634Cellular Componentnucleus
GO:0008270Molecular Functionzinc ion binding
GO:0019789Molecular FunctionSUMO transferase activity
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 374 aa     Download sequence    Send to blast
MNSQNLQIYQ SLPNHNKKRL NQEQIKLLES SFDSTKKLEP EKKLQLSREL GVPPRQISIW  60
YQNRRARWKN QNLEIDYNAL QLKLETALSE KLQLEKETER LRGELQKANQ MLIEINGERA  120
INIPLGDVSL SSYYEEGGSS SFHEDVISYN TTTWEIRKAV TMMKDIAVDL ERDERTEMVK  180
DLEAGVIQLL GASDECMHLS EAIQSIGDEL EPGPEPTNFK KKFDEEIAKS KARSLSSTQS  240
QPLLRQFREA IWHVHHAGQP MPGEEQEDIV MTSTQCNLLN VTCPLSGKPV TELVDPVRSM  300
DCKHIYEKKA ILQFIKSKTS RGQCPVAGCP KVLQAQRVLC DPFLLIEIDE VRSMSKQNAG  360
PDAIEDFTTL DEED
Functional Description ? help Back to Top
Source Description
UniProtE3 SUMO-protein ligase that modulates cell cycle progression and functions as a repressor of endocycle onset in meristems. May function downstream of the meristem patterning transcription factors PLETHORA 1 and 2 (PLT1 and PLT2) in root meristem development. Modulates the expression of the mitotic cyclins CYCB1-1 and CYCB1-2 and cyclin-dependent kinases CDKB1-1 and CDKB2-1 in root meristem. Involved in cytokinin signaling in root development. {ECO:0000269|PubMed:19666737, ECO:0000269|PubMed:19682286}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankHG9754461e-45HG975446.1 Solanum pennellii chromosome ch07, complete genome.
GenBankHG9755191e-45HG975519.1 Solanum lycopersicum chromosome ch07, complete genome.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009591846.10.0PREDICTED: E3 SUMO-protein ligase MMS21 isoform X1
SwissprotQ8GYH75e-84NSE2_ARATH; E3 SUMO-protein ligase MMS21
TrEMBLA0A1J6INE01e-160A0A1J6INE0_NICAT; E3 sumo-protein ligase mms21
STRINGXP_009591846.10.0(Nicotiana tomentosiformis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA1074322
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G53980.16e-28homeobox protein 52
Publications ? help Back to Top
  1. Lee J, et al.
    Salicylic acid-mediated innate immunity in Arabidopsis is regulated by SIZ1 SUMO E3 ligase.
    Plant J., 2007. 49(1): p. 79-90
    [PMID:17163880]
  2. Huang L, et al.
    The Arabidopsis SUMO E3 ligase AtMMS21, a homologue of NSE2/MMS21, regulates cell proliferation in the root.
    Plant J., 2009. 60(4): p. 666-78
    [PMID:19682286]
  3. Zhang S,Qi Y,Yang C
    Arabidopsis SUMO E3 ligase AtMMS21 regulates root meristem development.
    Plant Signal Behav, 2010. 5(1): p. 53-5
    [PMID:20592809]
  4. Ishida T,Yoshimura M,Miura K,Sugimoto K
    MMS21/HPY2 and SIZ1, two Arabidopsis SUMO E3 ligases, have distinct functions in development.
    PLoS ONE, 2012. 7(10): p. e46897
    [PMID:23056518]
  5. Zhang S,Qi Y,Liu M,Yang C
    SUMO E3 ligase AtMMS21 regulates drought tolerance in Arabidopsis thaliana(F).
    J Integr Plant Biol, 2013. 55(1): p. 83-95
    [PMID:23231763]
  6. Xu P, et al.
    AtMMS21, an SMC5/6 complex subunit, is involved in stem cell niche maintenance and DNA damage responses in Arabidopsis roots.
    Plant Physiol., 2013. 161(4): p. 1755-68
    [PMID:23426194]
  7. Okushima Y,Shimizu K,Ishida T,Sugimoto K,Umeda M
    Differential regulation of B2-type CDK accumulation in Arabidopsis roots.
    Plant Cell Rep., 2014. 33(7): p. 1033-40
    [PMID:24573537]
  8. Yuan D, et al.
    AtMMS21 regulates DNA damage response and homologous recombination repair in Arabidopsis.
    DNA Repair (Amst.), 2014. 21: p. 140-7
    [PMID:24795278]
  9. Liu M, et al.
    SUMO E3 ligase AtMMS21 is required for normal meiosis and gametophyte development in Arabidopsis.
    BMC Plant Biol., 2014. 14: p. 153
    [PMID:24893774]
  10. Kwak JS,Son GH,Kim SI,Song JT,Seo HS
    Arabidopsis HIGH PLOIDY2 Sumoylates and Stabilizes Flowering Locus C through Its E3 Ligase Activity.
    Front Plant Sci, 2016. 7: p. 530
    [PMID:27148346]
  11. Liu Y, et al.
    The Arabidopsis SUMO E3 Ligase AtMMS21 Dissociates the E2Fa/DPa Complex in Cell Cycle Regulation.
    Plant Cell, 2016. 28(9): p. 2225-2237
    [PMID:27492969]
  12. Liu L, et al.
    Transcriptional Gene Silencing Maintained by OTS1 SUMO Protease Requires a DNA-Dependent Polymerase V-Dependent Pathway.
    Plant Physiol., 2017. 173(1): p. 655-667
    [PMID:27852949]
  13. Zhang J, et al.
    A SUMO Ligase AtMMS21 Regulates the Stability of the Chromatin Remodeler BRAHMA in Root Development.
    Plant Physiol., 2017. 173(3): p. 1574-1582
    [PMID:28115583]
  14. Yu M, et al.
    A SUMO ligase AtMMS21 regulates activity of the 26S proteasome in root development.
    Plant Sci., 2019. 280: p. 314-320
    [PMID:30824010]