PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_016444112.1
Organism
Nicotiana tabacum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family bHLH
Protein Properties Length: 612aa    MW: 67922.5 Da    PI: 7.0348
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_016444112.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH36.87e-12443489455
                     HHHHHHHHHHHHHHHHHHHHHCTSCC.C...TTS-STCHHHHHHHHHHHHHHH CS
             HLH   4 ahnerErrRRdriNsafeeLrellPk.askapskKlsKaeiLekAveYIksLq 55 
                     +h e+Er+RR+++N++f  Lr ++P+ +      K++Ka+ L  A+ +I +Lq
  XP_016444112.1 443 NHVEAERQRREKLNQRFYALRAVVPNiS------KMDKASLLGDAIAHITELQ 489
                     799***********************66......*****************99 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142151.5E-5552240IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088816.31439488IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474599.29E-18442504IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000832.65E-13442493No hitNo description
Gene3DG3DSA:4.10.280.102.1E-17443503IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000102.2E-9443489IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003535.6E-16445494IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 612 aa     Download sequence    Send to blast
MKIEMGLGNM LWSDEDKAMV AAVLGTKAFD YLMSSSVSAE CSLMAMGNDE NLQNKLSDLV  60
ERPNGANFSW NYAIFWQISR SKSGELVLGW GDGCCREPRE GEGSEITRIL NLRLENEAQQ  120
RMRKRVLEKL HMLFGGTDED NYAFGLDKVT DTEMFFLASM YFSFPRGEGG PGKCFGSGKY  180
VWLSDVMKSS VDYCSRSFLM KSAGMQTIVL IPTDVGVVEL GSVRAISESL ELVQSIKSCF  240
SSFLSLIRAK QAGSVTVVAE KKDGNNFPFS SSFISEQPPN GVPKIFGQNL NSGCTPFREK  300
LVVRKAEDRP LEMYQNGNRA QFLNARNGLR AASWASFSNV KPVNSADPYR PQIPANNVRD  360
FVNGAREEFR TNNFQHQKNA SMQIDFTNSR PVISPAHTVE SEHSDAEASC KEDHAGPVDD  420
KRPRKRGRKP ANGREEPLNH PLNHVEAERQ RREKLNQRFY ALRAVVPNIS KMDKASLLGD  480
AIAHITELQK KLRDMESESE RLGSTSRDAN ASASDSPSSE TQNRIPDINI EAANDEVVVR  540
VRCALETHPA SRVIEAFKEA RVNVVESKLA AGNDAVYHTF VVESSGSEQL TKEKLMAAFS  600
GESNALRPSP VR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4rqw_A9e-27482415193Transcription factor MYC3
4rqw_B9e-27482415193Transcription factor MYC3
4rru_A1e-2692365227Transcription factor MYC3
4rs9_A9e-27482415193Transcription factor MYC3
4ywc_A1e-2692365227Transcription factor MYC3
4ywc_B1e-2692365227Transcription factor MYC3
4yz6_A9e-27482415193Transcription factor MYC3
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1420428KRPRKRGRK
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor that negatively regulates jasmonate (JA) signaling (PubMed:30610166). Negatively regulates JA-dependent response to wounding, JA-induced expression of defense genes, JA-dependent responses against herbivorous insects, and JA-dependent resistance against Botrytis cinerea infection (PubMed:30610166). Plays a positive role in resistance against the bacterial pathogen Pseudomonas syringae pv tomato DC3000 (PubMed:30610166). {ECO:0000269|PubMed:30610166}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by wounding, feeding with herbivorous insects, infection with the fungal pathogen Botrytis cinerea and infection with the bacterial pathogen Pseudomonas syringae pv tomato DC3000. {ECO:0000269|PubMed:30610166}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_016444112.10.0PREDICTED: transcription factor bHLH13-like isoform X2
SwissprotA0A3Q7ELQ20.0MTB1_SOLLC; Transcription factor MTB1
TrEMBLA0A1S3XWN00.0A0A1S3XWN0_TOBAC; transcription factor bHLH13-like isoform X2
STRINGXP_009627739.10.0(Nicotiana tomentosiformis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA35852348
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G01260.30.0bHLH family protein
Publications ? help Back to Top
  1. Tomato Genome Consortium
    The tomato genome sequence provides insights into fleshy fruit evolution.
    Nature, 2012. 485(7400): p. 635-41
    [PMID:22660326]
  2. Sun H,Fan HJ,Ling HQ
    Genome-wide identification and characterization of the bHLH gene family in tomato.
    BMC Genomics, 2015. 16: p. 9
    [PMID:25612924]
  3. Liu Y, et al.
    MYC2 Regulates the Termination of Jasmonate Signaling via an Autoregulatory Negative Feedback Loop.
    Plant Cell, 2019. 31(1): p. 106-127
    [PMID:30610166]