PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_016445952.1
Common NameNTH9
Organism
Nicotiana tabacum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family TALE
Protein Properties Length: 279aa    MW: 31577.2 Da    PI: 4.8161
Description TALE family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_016445952.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox26.41.1e-082252582255
                     SSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHH CS
        Homeobox  22 nrypsaeereeLAkklgLterqVkvWFqNrRake 55 
                      +yp++ e+  LA+++gL+ +q+ +WF N+R ++
  XP_016445952.1 225 WPYPTEGEKICLAESTGLDPKQINNWFINQRKRH 258
                     58*****************************885 PP
2ELK40.17.4e-14178199122
             ELK   1 ELKhqLlrKYsgyLgsLkqEFs 22 
                     E+K+ L+rKYsgy++sLkqEFs
  XP_016445952.1 178 EIKDKLMRKYSGYISSLKQEFS 199
                     89*******************8 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM012552.3E-1278123IPR005540KNOX1
PfamPF037903.9E-1680117IPR005540KNOX1
PROSITE profilePS5121310.964178198IPR005539ELK domain
SMARTSM011881.3E-7178199IPR005539ELK domain
PfamPF037896.1E-11178199IPR005539ELK domain
PROSITE profilePS5007111.936198261IPR001356Homeobox domain
SuperFamilySSF466897.7E-20200272IPR009057Homeodomain-like
SMARTSM003891.0E-10200265IPR001356Homeobox domain
CDDcd000862.71E-12201262No hitNo description
Gene3DG3DSA:1.10.10.601.1E-27203263IPR009057Homeodomain-like
PfamPF059201.4E-16218257IPR008422Homeobox KN domain
PROSITE patternPS000270236259IPR017970Homeobox, conserved site
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 279 aa     Download sequence    Send to blast
MEKMYEFVSS SSDVYSVEDN LQPPYFGSPP AFCDGLAPMG FGSGNMSWAC PETSAANLVV  60
DKSGTSSSNL QLEDHPETDI RAKISSHPLY PKLLRTYIDC HKVGAPSDEI VDMLDNINIV  120
HENDLSRRSN RLSDDSELDA FMFVSKDEGA AGTEEEEEVA DTSGGGGNTN DMCRSENEIK  180
DKLMRKYSGY ISSLKQEFSK KNKKGKLPRE ARQILLNWWT THYKWPYPTE GEKICLAEST  240
GLDPKQINNW FINQRKRHWK PSENMQYAVM ESIYGHFSE
Functional Description ? help Back to Top
Source Description
UniProtMay play a role in meristem function, and may be involved in maintaining cells in an undifferentiated, meristematic state. Probably binds to the DNA sequence 5'-TGAC-3'.
UniProtPlays a role in meristem function. Contributes to the shoot apical meristem (SAM) maintenance and organ separation by controlling boundary establishment in embryo in a CUC1, CUC2 and STM-dependent manner. Involved in maintaining cells in an undifferentiated, meristematic state. Probably binds to the DNA sequence 5'-TGAC-3'. {ECO:0000269|PubMed:16798887}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Seems to be repressed by AS2 and AS1 but induced by STM, CUC1 and CUC2. {ECO:0000269|PubMed:11311158, ECO:0000269|PubMed:16798887}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAB0257130.0AB025713.1 Nicotiana tabacum mRNA for homeobox 9, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_016445952.10.0PREDICTED: homeobox protein knotted-1-like 2
SwissprotP466404e-57KNAT2_ARATH; Homeobox protein knotted-1-like 2
SwissprotQ84JS64e-57KNAT6_ARATH; Homeobox protein knotted-1-like 6
TrEMBLA0A1S3Y1T40.0A0A1S3Y1T4_TOBAC; homeobox protein knotted-1-like 2
STRINGXP_009618137.10.0(Nicotiana tomentosiformis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA7532480
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G23380.13e-45KNOTTED1-like homeobox gene 6
Publications ? help Back to Top
  1. Nishimura A,Tamaoki M,Sato Y,Matsuoka M
    The expression of tobacco knotted1-type class 1 homeobox genes correspond to regions predicted by the cytohistological zonation model.
    Plant J., 1999. 18(4): p. 337-47
    [PMID:10406119]
  2. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  3. Zhang XL,Yang ZP,Zhang J,Zhang LG
    Ectopic expression of BraYAB1-702, a member of YABBY gene family in Chinese cabbage, causes leaf curling, inhibition of development of shoot apical meristem and flowering stage delaying in Arabidopsis thaliana.
    Int J Mol Sci, 2013. 14(7): p. 14872-91
    [PMID:23863694]
  4. Kuijt SJ, et al.
    Interaction between the GROWTH-REGULATING FACTOR and KNOTTED1-LIKE HOMEOBOX families of transcription factors.
    Plant Physiol., 2014. 164(4): p. 1952-66
    [PMID:24532604]
  5. Scofield S,Dewitte W,Murray JA
    STM sustains stem cell function in the Arabidopsis shoot apical meristem and controls KNOX gene expression independently of the transcriptional repressor AS1.
    Plant Signal Behav, 2018.
    [PMID:24776954]
  6. Lee JE,Lampugnani ER,Bacic A,Golz JF
    SEUSS and SEUSS-LIKE 2 coordinate auxin distribution and KNOXI activity during embryogenesis.
    Plant J., 2014. 80(1): p. 122-35
    [PMID:25060324]
  7. Machida C,Nakagawa A,Kojima S,Takahashi H,Machida Y
    The complex of ASYMMETRIC LEAVES (AS) proteins plays a central role in antagonistic interactions of genes for leaf polarity specification in Arabidopsis.
    Wiley Interdiscip Rev Dev Biol, 2015 Nov-Dec. 4(6): p. 655-71
    [PMID:26108442]
  8. Khan M, et al.
    Repression of Lateral Organ Boundary Genes by PENNYWISE and POUND-FOOLISH Is Essential for Meristem Maintenance and Flowering in Arabidopsis.
    Plant Physiol., 2015. 169(3): p. 2166-86
    [PMID:26417006]
  9. Li Z, et al.
    Transcription factors AS1 and AS2 interact with LHP1 to repress KNOX genes in Arabidopsis.
    J Integr Plant Biol, 2016. 58(12): p. 959-970
    [PMID:27273574]
  10. Lozano-Sotomayor P, et al.
    Altered expression of the bZIP transcription factor DRINK ME affects growth and reproductive development in Arabidopsis thaliana.
    Plant J., 2016. 88(3): p. 437-451
    [PMID:27402171]