PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_016448531.1
Organism
Nicotiana tabacum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family bHLH
Protein Properties Length: 379aa    MW: 42882.3 Da    PI: 5.6939
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_016448531.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH38.22.6e-12178229155
                     CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
             HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                     +r++h ++Er+RR+++N+ +  Lr+l+P +   + ++ + a+i   A+e++++L+
  XP_016448531.1 178 QRMTHIAVERNRRKQMNEHLRVLRSLMPGS---YVQRGDQASIIGGAIEFVRELE 229
                     79****************************...9*****************9995 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:4.10.280.101.3E-13176232IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000831.08E-12176233No hitNo description
SuperFamilySSF474591.83E-16177242IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088815.428177228IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.2E-9178229IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003533.4E-9183234IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF550215.8E-5305369No hitNo description
CDDcd048735.50E-4305369No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 379 aa     Download sequence    Send to blast
MEKRENSQPS LPTTFQMVGE TSHVANNSNQ MVDYLLNSHS TQQQQQQQQQ QHESSLGFCP  60
PGTSLDKLSF ADVMQFADFG PKLALNQAKV SEEDAGIDPV YFLKFPVLNE KTLQDDDQEA  120
LIVPHKEEKF KVVEEKANTS MQLPYVGENL ERSPGNEGSK SNKRKRPRVK TTEEVESQRM  180
THIAVERNRR KQMNEHLRVL RSLMPGSYVQ RGDQASIIGG AIEFVRELEQ LLQCLESQKR  240
RRIYGDNGPR PLGDNSTIQN PNTPQQPLIF PLPNDYIEAG IQEETAESKS CLADVEVKLL  300
GFDAMIKILS RRRPGQLIKT IAALEDMQLN ILHTNITTIE QTVLYSFNVK ISGETRYTAD  360
DIANSIQQIF SFIHANSPI
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1178189RMTHIAVERNRR
2238242KRRRI
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankHG9755172e-90HG975517.1 Solanum lycopersicum chromosome ch05, complete genome.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_016448531.10.0PREDICTED: transcription factor FAMA-like isoform X2
SwissprotQ56YJ81e-138FAMA_ARATH; Transcription factor FAMA
TrEMBLA0A1S3Y8960.0A0A1S3Y896_TOBAC; transcription factor FAMA-like isoform X2
STRINGXP_009623659.10.0(Nicotiana tomentosiformis)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G24140.11e-127bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]