PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_016458468.1
Organism
Nicotiana tabacum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family AP2
Protein Properties Length: 515aa    MW: 56936.1 Da    PI: 7.6659
Description AP2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_016458468.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP251.42.7e-16182241155
             AP2   1 sgykGVrwdkkrgrWvAeIrd.pse.ng..kr.krfslgkfgtaeeAakaaiaarkkleg 55 
                     s+y+GV++++++gr++A+++d  ++  g  ++ ++++lg ++ +e+Aa+a++ a++k++g
  XP_016458468.1 182 SQYRGVTRHRWTGRYEAHLWDnSCKkEGqtRKgRQVYLGGYDMEEKAARAYDLAALKYWG 241
                     78*******************988886678446*************************98 PP
2AP245.71.6e-14286335355
             AP2   3 ykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 
                     y+GV+++++ grW A+I  +     +k  +lg+f t eeAa+a++ a+ k++g
  XP_016458468.1 286 YRGVTRHHQHGRWQARIGRVAG---NKDLYLGTFSTQEEAAEAYDVAAIKFRG 335
                     9***************988532...5************************997 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000184.90E-22182249No hitNo description
SuperFamilySSF541717.85E-17182251IPR016177DNA-binding domain
PfamPF008476.5E-13182241IPR001471AP2/ERF domain
PROSITE profilePS5103219.203183249IPR001471AP2/ERF domain
SMARTSM003803.8E-29183255IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.103.3E-16183250IPR001471AP2/ERF domain
PRINTSPR003672.0E-6184195IPR001471AP2/ERF domain
CDDcd000181.59E-25284345No hitNo description
SuperFamilySSF541716.47E-18284345IPR016177DNA-binding domain
PROSITE profilePS5103219.282285343IPR001471AP2/ERF domain
SMARTSM003804.9E-34285349IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.101.1E-18285343IPR001471AP2/ERF domain
PfamPF008477.7E-10286335IPR001471AP2/ERF domain
PRINTSPR003672.0E-6325345IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 515 aa     Download sequence    Send to blast
MVQSSSSPKL EDFLGGASQY GNHEREAMAL SLDSLYYHQN EGYYSPMHCH GMYQESLLDE  60
TKPTQISHCD AQMTAVSGNE LKSWGHYAID QHINETCSSM VGAGGGGGTS GSGGGTVGGN  120
DLQSLSLSMN PGSQSSCVTP RQISPNELEC VAIETKKRAS GKVVQKQPVH RKSIDTFGQR  180
TSQYRGVTRH RWTGRYEAHL WDNSCKKEGQ TRKGRQVYLG GYDMEEKAAR AYDLAALKYW  240
GPSTHINFPL ENYQKELEDM KNMTRQEYVA HLRRKSSGFS RGASMYRGVT RHHQHGRWQA  300
RIGRVAGNKD LYLGTFSTQE EAAEAYDVAA IKFRGVNAVT NFDISRYDVE KIMASNTLPA  360
GELARRNKER EPIEYNLSDH KNEEACVQND NNNNNGNNVT DWKMVSYQSS NPSLGNYRNP  420
TFSMALQDLI GIDLMNSSNH PILDDQQNKI GNHFSNASSL VTSLGSSREA SPDKSAASLV  480
FAKPTNVNAC IPSAQLRPIP VSISHLPVFA ALNDA
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that recognizes and binds to the DNA consensus sequence 5'-CAC[AG]N[AT]TNCCNANG-3'. Required for the initiation and growth of ovules integumenta, and for the development of female gametophyte. Plays a critical role in the development of gynoecium marginal tissues (e.g. stigma, style and septa), and in the fusion of carpels and of medial ridges leading to ovule primordia. Also involved in organs initiation and development, including floral organs. Maintains the meristematic competence of cells and consequently sustains expression of cell cycle regulators during organogenesis, thus controlling the final size of each organ by controlling their cell number. Regulates INO autoinduction and expression pattern. As ANT promotes petal cell identity and mediates down-regulation of AG in flower whorl 2, it functions as a class A homeotic gene. {ECO:0000269|PubMed:10528263, ECO:0000269|PubMed:10639184, ECO:0000269|PubMed:10948255, ECO:0000269|PubMed:11041883, ECO:0000269|PubMed:12183381, ECO:0000269|PubMed:12271029, ECO:0000269|PubMed:12655002, ECO:0000269|PubMed:8742706, ECO:0000269|PubMed:8742707, ECO:0000269|PubMed:9001406, ECO:0000269|PubMed:9093862, ECO:0000269|PubMed:9118807}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAY4614320.0AY461432.1 Nicotiana tabacum ANT-like protein mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001312262.10.0AP2-like ethylene-responsive transcription factor ANT
SwissprotQ389141e-147ANT_ARATH; AP2-like ethylene-responsive transcription factor ANT
TrEMBLQ6SA750.0Q6SA75_TOBAC; ANT-like protein
STRINGXP_009776255.10.0(Nicotiana sylvestris)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G37750.11e-144AP2 family protein
Publications ? help Back to Top
  1. Rieu I,Bots M,Mariani C,Weterings KA
    Isolation and expression analysis of a tobacco AINTEGUMENTA ortholog (NtANTL).
    Plant Cell Physiol., 2005. 46(5): p. 803-5
    [PMID:15746156]
  2. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  3. Horstman A,Willemsen V,Boutilier K,Heidstra R
    AINTEGUMENTA-LIKE proteins: hubs in a plethora of networks.
    Trends Plant Sci., 2014. 19(3): p. 146-57
    [PMID:24280109]
  4. Li C, et al.
    Ectopic expression of a maize hybrid down-regulated gene ZmARF25 decreases organ size by affecting cellular proliferation in Arabidopsis.
    PLoS ONE, 2014. 9(4): p. e94830
    [PMID:24756087]
  5. Wynn AN,Seaman AA,Jones AL,Franks RG
    Novel functional roles for PERIANTHIA and SEUSS during floral organ identity specification, floral meristem termination, and gynoecial development.
    Front Plant Sci, 2014. 5: p. 130
    [PMID:24778638]
  6. Randall RS, et al.
    AINTEGUMENTA and the D-type cyclin CYCD3;1 regulate root secondary growth and respond to cytokinins.
    Biol Open, 2015. 4(10): p. 1229-36
    [PMID:26340943]
  7. Meng LS,Wang ZB,Yao SQ,Liu A
    The ARF2-ANT-COR15A gene cascade regulates ABA-signaling-mediated resistance of large seeds to drought in Arabidopsis.
    J. Cell. Sci., 2015. 128(21): p. 3922-32
    [PMID:26395398]
  8. Yamaguchi N,Jeong CW,Nole-Wilson S,Krizek BA,Wagner D
    AINTEGUMENTA and AINTEGUMENTA-LIKE6/PLETHORA3 Induce LEAFY Expression in Response to Auxin to Promote the Onset of Flower Formation in Arabidopsis.
    Plant Physiol., 2016. 170(1): p. 283-93
    [PMID:26537561]
  9. Krizek BA, et al.
    RNA-Seq Links the Transcription Factors AINTEGUMENTA and AINTEGUMENTA-LIKE6 to Cell Wall Remodeling and Plant Defense Pathways.
    Plant Physiol., 2016. 171(3): p. 2069-84
    [PMID:27208279]
  10. Han H,Krizek BA
    AINTEGUMENTA-LIKE6 can functionally replace AINTEGUMENTA but alters Arabidopsis flower development when misexpressed at high levels.
    Plant Mol. Biol., 2016. 92(4-5): p. 597-612
    [PMID:27605095]
  11. Karpinska B,Alomrani SO,Foyer CH
    Inhibitor-induced oxidation of the nucleus and cytosol in Arabidopsis thaliana: implications for organelle to nucleus retrograde signalling.
    Philos. Trans. R. Soc. Lond., B, Biol. Sci., 2018.
    [PMID:28808105]
  12. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]