PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

XP_016464860.1

Organism

Nicotiana tabacum

Taxonomic ID

4097

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana

Family

bHLH

Protein Properties

Length: 233aa MW: 25777.2 Da PI: 8.662

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_016464860.1	genome	NCBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	36	1.2e-11	78	125	4	54
HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS HLH 4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 ++ rE++RRdr+N++f eL ll + + +K +K++iL Av+ + +L XP_016464860.1 78 SKACREKQRRDRLNDKFTELGALLEPG---RPPKTDKSAILVDAVRMVTQL 125 5678********************8...89************99988 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS50888	13.268	74	125	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamily	SSF47459	8.51E-13	77	144	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd00083	2.31E-8	77	130	No hit	No description
Pfam	PF00010	2.6E-9	78	125	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Gene3D	G3DSA:4.10.280.10	3.0E-13	78	148	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SMART	SM00353	6.7E-9	80	131	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 233 aa Download sequence Send to blast
MVSPENTNWL YDYGFEESAV PDSNFSATAS GFNWPMQNLN GSRNVSAEVD GSIGESDYPK 60 ENGSKKRARV ESCAPTSSKA CREKQRRDRL NDKFTELGAL LEPGRPPKTD KSAILVDAVR 120 MVTQLRGEAQ KLKDSNLNLQ EKIKELKAEK NELRDEKQKL KAEKEKLEQQ LKTTNAQPGF 180 LPPAIPAAFA PHGQVPGSKL VPIMSYPGVA MWQFMPPAAV DTSQDHVLRP PVA

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor. Plays a role in resistance to amide-linked indole-3-acetic acid (IAA) conjugates such as IAA-Leu and IAA-Phe. May regulate gene expression in response to metal homeostasis changes. {ECO:0000269\|PubMed:17028341}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	EU880279	0.0	EU880279.1 Nicotiana tabacum basic helix-loop-helix protein mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_001312372.1	1e-173	transcription factor ILR3-like
Refseq	XP_009791575.1	1e-173	PREDICTED: transcription factor ILR3-like
Swissprot	Q9FH37	1e-112	ILR3_ARATH; Transcription factor ILR3
TrEMBL	A0A1U7XYG5	1e-172	A0A1U7XYG5_NICSY; transcription factor ILR3-like
TrEMBL	B5AYF5	1e-172	B5AYF5_TOBAC; Basic helix-loop-helix protein
STRING	XP_009791575.1	1e-172	(Nicotiana sylvestris)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA950	24	82

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G54680.1	2e-96	bHLH family protein

Publications ? help Back to Top
Ko DK,Lee MO,Hahn JS,Kim BG,Hong CB Submergence-inducible and circadian rhythmic basic helix-loop-helix protein gene in Nicotiana tabacum. J. Plant Physiol., 2009. 166(10): p. 1090-100 [PMID:19215997] Li X,Zhang H,Ai Q,Liang G,Yu D Two bHLH Transcription Factors, bHLH34 and bHLH104, Regulate Iron Homeostasis in Arabidopsis thaliana. Plant Physiol., 2016. 170(4): p. 2478-93 [PMID:26921305] Aparicio F,Pallás V The coat protein of Alfalfa mosaic virus interacts and interferes with the transcriptional activity of the bHLH transcription factor ILR3 promoting salicylic acid-dependent defence signalling response. Mol. Plant Pathol., 2017. 18(2): p. 173-186 [PMID:26929142] Liang G,Zhang H,Li X,Ai Q,Yu D bHLH transcription factor bHLH115 regulates iron homeostasis in Arabidopsis thaliana. J. Exp. Bot., 2017. 68(7): p. 1743-1755 [PMID:28369511] Ezer D, et al. The G-Box Transcriptional Regulatory Code in Arabidopsis. Plant Physiol., 2017. 175(2): p. 628-640 [PMID:28864470] Li B, et al. Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis. Plant Cell, 2018. 30(1): p. 178-195 [PMID:29317470] Min JH, et al. Arabidopsis Basic Helix-Loop-Helix 34 (bHLH34) Is Involved in Glucose Signaling through Binding to a GAGA Cis-Element. Front Plant Sci, 2017. 8: p. 2100 [PMID:29321786] Samira R, et al. The bHLH transcription factor ILR3 modulates multiple stress responses in Arabidopsis. Plant Mol. Biol., 2018. 97(4-5): p. 297-309 [PMID:29882068]