PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_016491022.1
Organism
Nicotiana tabacum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family AP2
Protein Properties Length: 551aa    MW: 60967.7 Da    PI: 6.5122
Description AP2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_016491022.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP2476.3e-15174233155
             AP2   1 sgykGVrwdkkrgrWvAeIrd.pse.ng..kr.krfslgkfgtaeeAakaaiaarkkleg 55 
                     s y+GV++++++gr++A+++d  +   g  ++ ++++lg ++ +e+Aa+a++ a++k++g
  XP_016491022.1 174 SIYRGVTRHRWTGRYEAHLWDnSCRrEGqsRKgRQVYLGGYDKEEKAARAYDLAALKYWG 233
                     57*******************666664477446*************************98 PP
2AP247.54.6e-15278327355
             AP2   3 ykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 
                     y+GV+++++ grW A+I  +     +k  +lg+f t+eeAa+a++ a+ k++g
  XP_016491022.1 278 YRGVTRHHQHGRWQARIGRVAG---NKDLYLGTFTTEEEAAEAYDIAAIKFRG 327
                     9***************988532...5************************998 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF008477.2E-12174233IPR001471AP2/ERF domain
SuperFamilySSF541712.68E-17174243IPR016177DNA-binding domain
CDDcd000183.15E-23174243No hitNo description
SMARTSM003805.8E-30175247IPR001471AP2/ERF domain
PROSITE profilePS5103219.256175241IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.107.8E-16175242IPR001471AP2/ERF domain
PRINTSPR003673.7E-6176187IPR001471AP2/ERF domain
SuperFamilySSF541717.85E-18276336IPR016177DNA-binding domain
CDDcd000184.59E-24276335No hitNo description
SMARTSM003801.1E-31277341IPR001471AP2/ERF domain
PROSITE profilePS5103219.296277335IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.105.3E-18277335IPR001471AP2/ERF domain
PfamPF008472.8E-9278327IPR001471AP2/ERF domain
PRINTSPR003673.7E-6317337IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 551 aa     Download sequence    Send to blast
MNSNNWLSFP LSPTHSSLPP HLQTTQSHHF TLGLVNETID NPFHNQEWNL MNTQGSNEVP  60
KVADFLGVNK SDENQSELVH YNEIQSNDSD YLFQNNSVMP MQNALAPTGN YELQENACNI  120
QSLTLSMGSG KGSTSETSAS PSATTTVNAS ENSNTSIVEA APRRTLDTFG QRTSIYRGVT  180
RHRWTGRYEA HLWDNSCRRE GQSRKGRQVY LGGYDKEEKA ARAYDLAALK YWGTSTTTNF  240
PISNYEKELE DMKHMTRQEF VAAIRRKSSG FSRGASMYRG VTRHHQHGRW QARIGRVAGN  300
KDLYLGTFTT EEEAAEAYDI AAIKFRGLNA VTNFDMNRYD VKAILESNTL PIGGGAAKRL  360
KEAQALESSR KRDQEMIALN SSFQYGNSST SNNPLHAYPL LQQQPFSIES HQPLMTLENQ  420
EPSHFHQSYL QTQLQLHPAV QTSHYDSTHQ FYNNYLQSNP VFLHGLMENG GGSSSTGSYS  480
TGGYFGNSTG LGGISSNSTS NGVGGGGNGE EVALVKVDYD NMPVNGSNYN GWSGDSSVQG  540
SNPGVFSMWN D
Functional Description ? help Back to Top
Source Description
UniProtProbably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). Master regulator of basal/root fate. Essential for root quiescent center (QC) and columella specification, stem cell activity, as well as for establishment of the stem cell niche during embryogenesis. Modulates the root polar auxin transport by regulating the distribution of PIN genes. Essential role in respecifying pattern and polarity in damaged roots. Direct target of the transcriptional corepressor TPL. Expression levels and patterns regulated post-transcriptionally by root meristem growth factors (RGFs). {ECO:0000250, ECO:0000269|PubMed:15454085, ECO:0000269|PubMed:15635403, ECO:0000269|PubMed:16424342, ECO:0000269|PubMed:20190735}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By auxin accumulation. {ECO:0000269|PubMed:15454085}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009801580.10.0PREDICTED: AP2-like ethylene-responsive transcription factor PLT2 isoform X2
RefseqXP_016491022.10.0PREDICTED: AP2-like ethylene-responsive transcription factor PLT2
SwissprotQ5YGP70.0PLET2_ARATH; AP2-like ethylene-responsive transcription factor PLT2
TrEMBLA0A1S4BQ540.0A0A1S4BQ54_TOBAC; AP2-like ethylene-responsive transcription factor PLT2
TrEMBLA0A1U7YRW80.0A0A1U7YRW8_NICSY; AP2-like ethylene-responsive transcription factor PLT2 isoform X2
STRINGXP_009801579.10.0(Nicotiana sylvestris)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA22462457
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G51190.10.0AP2 family protein
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Lee DK,Sieburth LE
    The bps signal: embryonic arrest from an auxin-independent mechanism in bypass triple mutants.
    Plant Signal Behav, 2012. 7(6): p. 698-700
    [PMID:22580686]
  3. Hong LW,Yan DW,Liu WC,Chen HG,Lu YT
    TIME FOR COFFEE controls root meristem size by changes in auxin accumulation in Arabidopsis.
    J. Exp. Bot., 2014. 65(1): p. 275-86
    [PMID:24277277]
  4. Tian H,Jia Y,Niu T,Yu Q,Ding Z
    The key players of the primary root growth and development also function in lateral roots in Arabidopsis.
    Plant Cell Rep., 2014. 33(5): p. 745-53
    [PMID:24504658]
  5. Zhao Q, et al.
    Sulfur nutrient availability regulates root elongation by affecting root indole-3-acetic acid levels and the stem cell niche.
    J Integr Plant Biol, 2014. 56(12): p. 1151-63
    [PMID:24831283]
  6. Huang JB, et al.
    ROP3 GTPase contributes to polar auxin transport and auxin responses and is important for embryogenesis and seedling growth in Arabidopsis.
    Plant Cell, 2014. 26(9): p. 3501-18
    [PMID:25217509]
  7. Yang S, et al.
    The Arabidopsis SWI2/SNF2 Chromatin Remodeling ATPase BRAHMA Targets Directly to PINs and Is Required for Root Stem Cell Niche Maintenance.
    Plant Cell, 2015. 27(6): p. 1670-80
    [PMID:25991732]
  8. Jia Y, et al.
    The Arabidopsis thaliana elongator complex subunit 2 epigenetically affects root development.
    J. Exp. Bot., 2015. 66(15): p. 4631-42
    [PMID:25998905]
  9. Zhang M, et al.
    A tetratricopeptide repeat domain-containing protein SSR1 located in mitochondria is involved in root development and auxin polar transport in Arabidopsis.
    Plant J., 2015. 83(4): p. 582-99
    [PMID:26072661]
  10. Shinohara H,Mori A,Yasue N,Sumida K,Matsubayashi Y
    Identification of three LRR-RKs involved in perception of root meristem growth factor in Arabidopsis.
    Proc. Natl. Acad. Sci. U.S.A., 2016. 113(14): p. 3897-902
    [PMID:27001831]
  11. Ou Y, et al.
    RGF1 INSENSITIVE 1 to 5, a group of LRR receptor-like kinases, are essential for the perception of root meristem growth factor 1 in Arabidopsis thaliana.
    Cell Res., 2016. 26(6): p. 686-98
    [PMID:27229312]
  12. Santuari L, et al.
    The PLETHORA Gene Regulatory Network Guides Growth and Cell Differentiation in Arabidopsis Roots.
    Plant Cell, 2016. 28(12): p. 2937-2951
    [PMID:27920338]
  13. Promchuea S,Zhu Y,Chen Z,Zhang J,Gong Z
    ARF2 coordinates with PLETHORAs and PINs to orchestrate ABA-mediated root meristem activity in Arabidopsis .
    J Integr Plant Biol, 2017. 59(1): p. 30-43
    [PMID:28074634]
  14. Du Y,Scheres B
    PLETHORA transcription factors orchestrate de novo organ patterning during Arabidopsis lateral root outgrowth.
    Proc. Natl. Acad. Sci. U.S.A., 2017. 114(44): p. 11709-11714
    [PMID:29078398]
  15. Bustillo-Avendaño E, et al.
    Regulation of Hormonal Control, Cell Reprogramming, and Patterning during De Novo Root Organogenesis.
    Plant Physiol., 2018. 176(2): p. 1709-1727
    [PMID:29233938]