PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID cra_locus_11368_iso_5
Organism
Catharanthus roseus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Gentianales; Apocynaceae; Rauvolfioideae; Vinceae; Catharanthinae; Catharanthus
Family ARF
Protein Properties Length: 824aa    MW: 91538.5 Da    PI: 6.374
Description ARF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
cra_locus_11368_iso_5genomeMPGR-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1B373.13.5e-23114215199
                                           EEEE-..-HHHHTT-EE--HHH.HTT.......---..--SEEEEEETTS-EEEEEE..EEETTEEEE-TTHH CS
                                    B3   1 ffkvltpsdvlksgrlvlpkkfaeeh.......ggkkeesktltledesgrsWevkliyrkksgryvltkGWk 66 
                                           f+k+lt sd++++g +++p++ ae+        +   +  ++l+ +d++  +W++++i+r++++r++lt+GW+
  cra_locus_11368_iso_5_len_2711_ver_3 114 FCKTLTASDTSTHGGFSVPRRAAEKVfppldfsQT--PPAQELIARDLHDVEWKFRHIFRGQPKRHLLTTGWS 184
                                           99*****************************7444..44459******************************* PP

                                           HHHHHHT--TT-EEEEEE-SSSEE..EEEEE-S CS
                                    B3  67 eFvkangLkegDfvvFkldgrsefelvvkvfrk 99 
                                            Fv+a++L +gD+v+F   ++++ +l+++++r+
  cra_locus_11368_iso_5_len_2711_ver_3 185 VFVSAKRLVAGDSVLFI--WNEKNQLLLGIRRA 215
                                           *****************..8899999****997 PP
2Auxin_resp120.31.5e-39240323183
                            Auxin_resp   1 aahaastksvFevvYnPrastseFvvkvekvekalk.vkvsvGmRfkmafetedsserrlsGtvvgvsdldpv 72 
                                           aahaa+t+s F+++YnPras+seFv++++k++ka++ ++vsvGmRf+m fete+ss rr++Gt++g+ dldpv
  cra_locus_11368_iso_5_len_2711_ver_3 240 AAHAAATNSCFTIFYNPRASPSEFVIPLSKYVKAVYhTRVSVGMRFRMLFETEESSVRRYMGTITGIGDLDPV 312
                                           79*********************************9789********************************** PP

                            Auxin_resp  73 rWpnSkWrsLk 83 
                                           rWpnS+Wrs+k
  cra_locus_11368_iso_5_len_2711_ver_3 313 RWPNSHWRSVK 323
                                           ********985 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF1019367.19E-4998243IPR015300DNA-binding pseudobarrel domain
Gene3DG3DSA:2.40.330.102.7E-41107229IPR015300DNA-binding pseudobarrel domain
CDDcd100172.48E-21113214No hitNo description
PfamPF023622.3E-21114215IPR003340B3 DNA binding domain
PROSITE profilePS5086312.308114216IPR003340B3 DNA binding domain
SMARTSM010191.1E-23114216IPR003340B3 DNA binding domain
PfamPF065071.0E-34240323IPR010525Auxin response factor
PfamPF023092.5E-7693785IPR033389AUX/IAA domain
SuperFamilySSF542779.81E-7694772No hitNo description
PROSITE profilePS5174523.073698782IPR000270PB1 domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009733Biological Processresponse to auxin
GO:0009908Biological Processflower development
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0005515Molecular Functionprotein binding
Sequence ? help Back to Top
Protein Sequence    Length: 824 aa     Download sequence    Send to blast
XGEKKCLNSE LWHACAGPLV SLPTVGSRVV YFPQGHSEQV AATTNKEIDA HIPNYPSLPP  60
QLICQLHNVT MHADVETDEV YAQMTLQPLT PQEQKDTYLP VELGTPSRQP TNYFCKTLTA  120
SDTSTHGGFS VPRRAAEKVF PPLDFSQTPP AQELIARDLH DVEWKFRHIF RGQPKRHLLT  180
TGWSVFVSAK RLVAGDSVLF IWNEKNQLLL GIRRATRPQT VMPSSVLSSD SMHIGLLAAA  240
AHAAATNSCF TIFYNPRASP SEFVIPLSKY VKAVYHTRVS VGMRFRMLFE TEESSVRRYM  300
GTITGIGDLD PVRWPNSHWR SVKVGWDEST AGERQPRVSL WEIEPLTTFP MYPSLFPLRL  360
KRPWYPGASS FQDGSSDAIN GMSWLRGETG EHGLHSLNFP SMGMFPWMQQ RIDPSVLRND  420
LNHQYQAMLA AGLQNFGGGD LMKQQLLQFQ TPVQYLQHAG GNNTMVQQQV LQQTVSPHML  480
PAQTQMLSDN LNRPAQQQVS NQNDEQQQQH TFQEAYAIQH DQLHQRQPSN LPSPSFSKTE  540
FSDSSGKFSA SVAPSSMQNV LGSLCSDGSG NLMNFSRTTQ NMLNDQPPQQ SWVSKFSPQV  600
NTCSSSVSLP PYPRKDDPGQ QEACGLDTHN QALYGSNIDS SALLLPTTVS SIGASSIEAG  660
MSSLPIGDSG FQSPLYGYMQ DSAELLHGAG QDSPTQTGTF VKVYKSGSVG RSLDITRFHS  720
YPELRRELGQ MFGIEGLLED PQRSGWQLVF VDRENDVLLL GDDPWEAFVN NVWYIKILSP  780
EDVQKLGKQE AEALTRNAAE RANSSSGDGR DMASRFTSLG SLEF
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4ldu_A1e-158334447388Auxin response factor 5
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtAuxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Seems to act as transcriptional activator. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Regulates both stamen and gynoecium maturation. Promotes jasmonic acid production. Partially redundant with ARF6. Involved in fruit initiation. Acts as an inhibitor to stop further carpel development in the absence of fertilization and the generation of signals required to initiate fruit and seed development. {ECO:0000269|PubMed:12036261, ECO:0000269|PubMed:16107481, ECO:0000269|PubMed:16829592}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00033PBMTransfer from AT5G37020Download
Motif logo
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Repressed by miR167. {ECO:0000269|PubMed:17021043}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_027079004.10.0auxin response factor 8-like
RefseqXP_027178498.10.0auxin response factor 8
RefseqXP_027178499.10.0auxin response factor 8
SwissprotQ9FGV10.0ARFH_ARATH; Auxin response factor 8
TrEMBLA0A068U2C00.0A0A068U2C0_COFCA; Auxin response factor
STRINGXP_009789648.10.0(Nicotiana sylvestris)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA38572339
Publications ? help Back to Top
  1. Liu N, et al.
    Down-regulation of AUXIN RESPONSE FACTORS 6 and 8 by microRNA 167 leads to floral development defects and female sterility in tomato.
    J. Exp. Bot., 2014. 65(9): p. 2507-20
    [PMID:24723401]
  2. Minato N, et al.
    The phytoplasmal virulence factor TENGU causes plant sterility by downregulating of the jasmonic acid and auxin pathways.
    Sci Rep, 2014. 4: p. 7399
    [PMID:25492247]
  3. Ortega-Amaro MA, et al.
    Overexpression of AtGRDP2, a novel glycine-rich domain protein, accelerates plant growth and improves stress tolerance.
    Front Plant Sci, 2014. 5: p. 782
    [PMID:25653657]
  4. Wang Y, et al.
    MicroRNA167-Directed Regulation of the Auxin Response Factors GmARF8a and GmARF8b Is Required for Soybean Nodulation and Lateral Root Development.
    Plant Physiol., 2015. 168(3): p. 984-99
    [PMID:25941314]
  5. Barik S, et al.
    Coevolution Pattern and Functional Conservation or Divergence of miR167s and their targets across Diverse Plant Species.
    Sci Rep, 2015. 5: p. 14611
    [PMID:26459056]
  6. Pashkovskiy PP,Kartashov AV,Zlobin IE,Pogosyan SI,Kuznetsov VV
    Blue light alters miR167 expression and microRNA-targeted auxin response factor genes in Arabidopsis thaliana plants.
    Plant Physiol. Biochem., 2016. 104: p. 146-54
    [PMID:27031426]
  7. Mlotshwa S,Pruss GJ,MacArthur JL,Reed JW,Vance V
    Developmental Defects Mediated by the P1/HC-Pro Potyviral Silencing Suppressor Are Not Due to Misregulation of AUXIN RESPONSE FACTOR 8.
    Plant Physiol., 2016. 172(3): p. 1853-1861
    [PMID:27688620]
  8. Wójcikowska B,Gaj MD
    Expression profiling of AUXIN RESPONSE FACTOR genes during somatic embryogenesis induction in Arabidopsis.
    Plant Cell Rep., 2017. 36(6): p. 843-858
    [PMID:28255787]
  9. Zhang GZ, et al.
    Ectopic expression of UGT84A2 delayed flowering by indole-3-butyric acid-mediated transcriptional repression of ARF6 and ARF8 genes in Arabidopsis.
    Plant Cell Rep., 2017. 36(12): p. 1995-2006
    [PMID:29027578]
  10. Zheng K, et al.
    Involvement of PACLOBUTRAZOL RESISTANCE6/KIDARI, an Atypical bHLH Transcription Factor, in Auxin Responses in Arabidopsis.
    Front Plant Sci, 2017. 8: p. 1813
    [PMID:29114256]
  11. Liu Z, et al.
    ARF2-ARF4 and ARF5 are Essential for Female and Male Gametophyte Development in Arabidopsis.
    Plant Cell Physiol., 2018. 59(1): p. 179-189
    [PMID:29145642]
  12. Ghelli R, et al.
    A Newly Identified Flower-Specific Splice Variant of AUXIN RESPONSE FACTOR8 Regulates Stamen Elongation and Endothecium Lignification in Arabidopsis.
    Plant Cell, 2018. 30(3): p. 620-637
    [PMID:29514943]