PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID cra_locus_5840_iso_1
Organism
Catharanthus roseus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Gentianales; Apocynaceae; Rauvolfioideae; Vinceae; Catharanthinae; Catharanthus
Family E2F/DP
Protein Properties Length: 405aa    MW: 45794.1 Da    PI: 9.6494
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
cra_locus_5840_iso_1genomeMPGR-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP72.54.5e-231984171
                              E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                                         rk+ksL+ll+++fl+l+ ++  +++ l+++a +L    v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  cra_locus_5840_iso_1_len_1434_ver_3 19 RKQKSLGLLCSNFLSLYDREGVETIGLDDAAARL---GV--ERRRIYDIVNVLESVGVLARKAKNRYTWKG 84
                                         79*****************999************...**..****************************98 PP
2E2F_TDP72.26e-23153233171
                              E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kek 64 
                                          rkeksL lltq+f+kl+ + + ++++l+++ak L+++      ++ k+RR+YDi+NVL +++ iek     ++k
  cra_locus_5840_iso_1_len_1434_ver_3 153 RKEKSLALLTQNFVKLFICMDMDMISLDDAAKILLKNgkdpsMTRSKVRRLYDIANVLASMKFIEKthhpdTRK 226
                                          79*********************************99****98889************************99** PP

                              E2F_TDP  65 neirwkg 71 
                                          +++rw g
  cra_locus_5840_iso_1_len_1434_ver_3 227 PAFRWLG 233
                                          *****87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.107.4E-261785IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.93E-151982IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.2E-271984IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.8E-202084IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.103.5E-22150234IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.2E-27153233IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.0E-17154233IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.9E-11155234IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 405 aa     Download sequence    Send to blast
MALNSFTPKE AGSEQIYCRK QKSLGLLCSN FLSLYDREGV ETIGLDDAAA RLGVERRRIY  60
DIVNVLESVG VLARKAKNRY TWKGFGAIPS ALQTLKDEGF KNNCSGDDGH SSARNSDDEE  120
DDRYSNATYS SQNDKQNPDP GQKPPGSSKF DNRKEKSLAL LTQNFVKLFI CMDMDMISLD  180
DAAKILLKNG KDPSMTRSKV RRLYDIANVL ASMKFIEKTH HPDTRKPAFR WLGIKGKSEI  240
CADPMALHVS KKRAFGTELT NTMIKRSKVI TKLDGDLGQA SKAQFQPQIK CEPMEDEVPR  300
SKFQVDAKTG VKSYQFGPFA PDLSPQYHNQ ALRDLFDHYV EAWKSWYVEV AEKNPVKLIS  360
XFFFLKIAEL SNNCKSATSF MTKRRWPVCT FSMPGKIPKA NFFVH
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A3e-37192254228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_027066581.10.0E2F transcription factor-like E2FE isoform X1
SwissprotQ8LSZ41e-107E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A068UCS70.0A0A068UCS7_COFCA; Uncharacterized protein
STRINGXP_009607525.11e-150(Nicotiana tomentosiformis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA25222457
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]