PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID cra_locus_6024_iso_1
Organism
Catharanthus roseus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Gentianales; Apocynaceae; Rauvolfioideae; Vinceae; Catharanthinae; Catharanthus
Family E2F/DP
Protein Properties Length: 408aa    MW: 46300.5 Da    PI: 9.5084
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
cra_locus_6024_iso_1genomeMPGR-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP66.82.7e-212994171
                              E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                                         rkek L++l+++flkl+++   + + l+++a++L    v  +rRRiYDi+N++e+++++++k+kn+++wkg
  cra_locus_6024_iso_1_len_1221_ver_3 29 RKEKFLGVLCSNFLKLYNRDGVESIGLDNAADQL---GV--ERRRIYDIVNIFESVGVLTRKAKNQYTWKG 94
                                         79999**************999************...**..****************************98 PP
2E2F_TDP69.25.1e-22139218171
                              E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kek 64 
                                          rkeksL+ll+q+f+kll + +++ ++l+ +a+ L+ +     ++++k+RR+YDi+NV+ ++nliek     + k
  cra_locus_6024_iso_1_len_1221_ver_3 139 RKEKSLGLLAQNFVKLLLS-SNELISLDRAASLLLGDirdptSMRTKVRRLYDIANVFASMNLIEKtrhpdSGK 211
                                          79**************995.778*******************************************9999999* PP

                              E2F_TDP  65 neirwkg 71 
                                          ++++w+g
  cra_locus_6024_iso_1_len_1221_ver_3 212 PAFKWIG 218
                                          *****98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.0E-242795IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013724.1E-252994IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467854.17E-142992IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.5E-183094IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.107.3E-21137219IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013727.7E-29139218IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.5E-18140218IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467854.63E-12141219IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 408 aa     Download sequence    Send to blast
XRLEESMSSS SPPFPSDSET KGGPSVYCRK EKFLGVLCSN FLKLYNRDGV ESIGLDNAAD  60
QLGVERRRIY DIVNIFESVG VLTRKAKNQY TWKGFTAIPQ ALEILMKGGL QEKFNASIXL  120
NSKADKSLEG SEPQKVDGRK EKSLGLLAQN FVKLLLSSNE LISLDRAASL LLGDIRDPTS  180
MRTKVRRLYD IANVFASMNL IEKTRHPDSG KPAFKWIGVQ GQLKQGSSAA LNEHESKRRA  240
GSDITNTCSK RYRADYSLDK KLKQTESTQN CALHQNIKDN GKSLFEQHQK PGSKDFEFGP  300
FKPSGVLNMR ISDKRNVEQI EDWDNLASLY QPRYRNEAIN DLFSHYAEAW RLWYAEADHK  360
EKTHLPDADA PLNPQYFKES KAFSKRSNFA PPHVLLKDSR SFEYDVFX
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A7e-31292044222Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_028059824.11e-129E2F transcription factor-like E2FF isoform X1
SwissprotQ8LSZ46e-98E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A484N8S01e-124A0A484N8S0_9ASTE; Uncharacterized protein
STRINGGorai.006G027400.11e-120(Gossypium raimondii)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA25222457
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]