PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

cra_locus_6334_iso_3

Organism

Catharanthus roseus

Taxonomic ID

4058

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Gentianales; Apocynaceae; Rauvolfioideae; Vinceae; Catharanthinae; Catharanthus

Family

NAC

Protein Properties

Length: 497aa MW: 56600.1 Da PI: 5.0545

Description

NAC family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
cra_locus_6334_iso_3	genome	MPGR	-

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	NAM	81.4	1.8e-25	58	182	1	116
NAM 1 lppGfrFhPtdeelvveyLkkkvegkk......leleevikevd....iykvePwdLpkkvkaeekewyfFskr 64 lp+G++F+P+d+e++++ L +kv+ ++ ++ e+i++vd i++++P++Lp vk++ + +fF+++ cra_locus_6334_iso_3_len_1962_ver_3 58 LPRGVKFDPSDQEIIWHLL-AKVRVRNlkphpfID--EFIPTVDeedgICYTHPQNLP-GVKQDGSVSHFFHRA 127 699**********6655.555555534654322..33555544446******.677888899** PP NAM 65 dkkyatgkrknratk.....sgyWkatgkdkevlskkgelvglkktLvfykgrapkg 116 k+y+tg+rk+r+++ + +W++tg++k+vl +g++ g+kk++v+y a+ g cra_locus_6334_iso_3_len_1962_ver_3 128 IKAYNTGTRKRRKIHgdsfgDVRWHKTGRTKPVLL-DGTQEGCKKIMVLYVSPAK-G 182 ********86555555788********.999*********43333.3 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF101941	1.57E-28	43	216	IPR003441	NAC domain
PROSITE profile	PS51005	22.585	58	216	IPR003441	NAC domain
Pfam	PF02365	3.0E-7	59	181	IPR003441	NAC domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0000077	Biological Process	DNA damage checkpoint
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0010332	Biological Process	response to gamma radiation
GO:0040020	Biological Process	regulation of meiotic nuclear division
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 497 aa Download sequence Send to blast
MARPSWLVDS NRIATKIKSA SGASDPQEIN WKSNPTKACP NCQYAIDNSD TTQEWPGLPR 60 GVKFDPSDQE IIWHLLAKVR VRNLKPHPFI DEFIPTVDEE DGICYTHPQN LPGVKQDGSV 120 SHFFHRAIKA YNTGTRKRRK IHGDSFGDVR WHKTGRTKPV LLDGTQEGCK KIMVLYVSPA 180 KGGKAEKXQL GDAPISPGNT GGEREGEYVI SKVFYQQPQL KLSEKNELEL LEDVDAMIVK 240 ADPVTPKLVT PEPPSTGKRL LGSDAGEVPI DPSTQDNLFL IVSYHIPATF WTCFAKIEVR 300 KRKKIVAEFY NIYFIVFFLL LLXLLTYLPK KDAHISLRIM CLDIFLVYPX HCEEEYMEDY 360 VEAPTEQLGC EDHISMEHQN SQKEEKNEND EEPKWWDGES QYLLDSQQLV EGLSLCDELL 420 QSQSPNRDGN RTDQELKNKP RLSDYAQLGT ESWKKDLEEC QNLVLDPPNM DHDAADFRLS 480 QIEFGSQDSY ISWGANK

Sequence ? help Back to Top

Protein Sequence Length: 497 aa Download sequence Send to blast

MARPSWLVDS NRIATKIKSA SGASDPQEIN WKSNPTKACP NCQYAIDNSD TTQEWPGLPR  60
GVKFDPSDQE IIWHLLAKVR VRNLKPHPFI DEFIPTVDEE DGICYTHPQN LPGVKQDGSV  120
SHFFHRAIKA YNTGTRKRRK IHGDSFGDVR WHKTGRTKPV LLDGTQEGCK KIMVLYVSPA  180
KGGKAEKXQL GDAPISPGNT GGEREGEYVI SKVFYQQPQL KLSEKNELEL LEDVDAMIVK  240
ADPVTPKLVT PEPPSTGKRL LGSDAGEVPI DPSTQDNLFL IVSYHIPATF WTCFAKIEVR  300
KRKKIVAEFY NIYFIVFFLL LLXLLTYLPK KDAHISLRIM CLDIFLVYPX HCEEEYMEDY  360
VEAPTEQLGC EDHISMEHQN SQKEEKNEND EEPKWWDGES QYLLDSQQLV EGLSLCDELL  420
QSQSPNRDGN RTDQELKNKP RLSDYAQLGT ESWKKDLEEC QNLVLDPPNM DHDAADFRLS  480
QIEFGSQDSY ISWGANK

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	299	303	RKRKK

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor regulating the transcriptional activation response to gamma irradiation (PubMed:19549833). Required for stem-cell death induced by UVB or by gamma irradiation (PubMed:20634150). Not required for ATM activation, but participates in pathways governed by both ATM and ATR sensor kinases (PubMed:19549833). Involved in DNA damage response (DDR) system that regulates cell cycle arrest (PubMed:24399300). Functional homolog of animal p53 (PubMed:24736489). Regulates SMR5 and SMR7 transcription (PubMed:24399300). Regulates DNA repair and cytokinin signaling separately and plays a key role in controlling lateral root formation under genotoxic stress. {ECO:0000269\|PubMed:19549833, ECO:0000269\|PubMed:20634150, ECO:0000269\|PubMed:24399300, ECO:0000305\|PubMed:24736489}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Not induced by zeocin or ionizing radiation treatment. {ECO:0000269\|PubMed:23907539}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_022867496.1	0.0	SUPPRESSOR OF GAMMA RESPONSE 1-like
Swissprot	Q6NQK2	1e-155	NAC8_ARATH; SUPPRESSOR OF GAMMA RESPONSE 1
TrEMBL	A0A2Z7BDI7	1e-175	A0A2Z7BDI7_9LAMI; NAC domain-containing protein 8-like
STRING	XP_004135409.1	1e-175	(Cucumis sativus)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA8162	24	30

Publications ? help Back to Top
Yi D, et al. The Arabidopsis SIAMESE-RELATED cyclin-dependent kinase inhibitors SMR5 and SMR7 regulate the DNA damage checkpoint in response to reactive oxygen species. Plant Cell, 2014. 26(1): p. 296-309 [PMID:24399300] Biever JJ,Brinkman D,Gardner G UV-B inhibition of hypocotyl growth in etiolated Arabidopsis thaliana seedlings is a consequence of cell cycle arrest initiated by photodimer accumulation. J. Exp. Bot., 2014. 65(11): p. 2949-61 [PMID:24591052] Hu Z,Cools T,Kalhorzadeh P,Heyman J,De Veylder L Deficiency of the Arabidopsis helicase RTEL1 triggers a SOG1-dependent replication checkpoint in response to DNA cross-links. Plant Cell, 2015. 27(1): p. 149-61 [PMID:25595823] Chen P,Umeda M DNA double-strand breaks induce the expression of flavin-containing monooxygenase and reduce root meristem size in Arabidopsis thaliana. Genes Cells, 2015. 20(8): p. 636-46 [PMID:26033196] Sjogren CA,Bolaris SC,Larsen PB Aluminum-Dependent Terminal Differentiation of the Arabidopsis Root Tip Is Mediated through an ATR-, ALT2-, and SOG1-Regulated Transcriptional Response. Plant Cell, 2015. 27(9): p. 2501-15 [PMID:26320227] Yoshiyama KO SOG1: a master regulator of the DNA damage response in plants. Genes Genet. Syst., 2016. 90(4): p. 209-16 [PMID:26617076] Weimer AK, et al. The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis. EMBO J., 2016. 35(19): p. 2068-2086 [PMID:27497297] Davis OM,Ogita N,Inagaki S,Takahashi N,Umeda M DNA damage inhibits lateral root formation by up-regulating cytokinin biosynthesis genes in Arabidopsis thaliana. Genes Cells, 2016. 21(11): p. 1195-1208 [PMID:27658920] Pedroza-García JA, et al. Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis. Plant Physiol., 2017. 173(3): p. 1735-1749 [PMID:28153919] Horvath BM, et al. Arabidopsis RETINOBLASTOMA RELATED directly regulates DNA damage responses through functions beyond cell cycle control. EMBO J., 2017. 36(9): p. 1261-1278 [PMID:28320736] Sjogren CA,Larsen PB SUV2, which encodes an ATR-related cell cycle checkpoint and putative plant ATRIP, is required for aluminium-dependent root growth inhibition in Arabidopsis. Plant Cell Environ., 2017. 40(9): p. 1849-1860 [PMID:28556304] Yoshiyama KO,Kaminoyama K,Sakamoto T,Kimura S Increased Phosphorylation of Ser-Gln Sites on SUPPRESSOR OF GAMMA RESPONSE1 Strengthens the DNA Damage Response in Arabidopsis thaliana. Plant Cell, 2017. 29(12): p. 3255-3268 [PMID:29208704] Johnson RA, et al. SUPPRESSOR OF GAMMA RESPONSE1 Links DNA Damage Response to Organ Regeneration. Plant Physiol., 2018. 176(2): p. 1665-1675 [PMID:29222192] Ogita N, et al. Identifying the target genes of SUPPRESSOR OF GAMMA RESPONSE 1, a master transcription factor controlling DNA damage response in Arabidopsis. Plant J., 2018. 94(3): p. 439-453 [PMID:29430765] Cao X, et al. Roles of MSH2 and MSH6 in cadmium-induced G2/M checkpoint arrest in Arabidopsis roots. Chemosphere, 2018. 201: p. 586-594 [PMID:29533809]