PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

cra_locus_9268_iso_2

Organism

Catharanthus roseus

Taxonomic ID

4058

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Gentianales; Apocynaceae; Rauvolfioideae; Vinceae; Catharanthinae; Catharanthus

Family

MYB_related

Protein Properties

Length: 308aa MW: 36560.6 Da PI: 7.281

Description

MYB_related family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
cra_locus_9268_iso_2	genome	MPGR	-

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Myb_DNA-binding	34.8	3.7e-11	79	120	4	46
S-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHH CS Myb_DNA-binding 4 WTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqk 46 W + E++ll++++k++G g+W +a+++g ++ + qc +++++ cra_locus_9268_iso_2_len_1569_ver_3 79 WNAKEELLLLEGIKMYGFGNWYEVAEHVG-TKDRTQCLDHYNS 120 ***************************.999999***85 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SMART	SM00291	2.5E-6	15	60	IPR000433	Zinc finger, ZZ-type
CDD	cd02335	6.51E-17	19	67	No hit	No description
PROSITE profile	PS50135	9.969	19	62	IPR000433	Zinc finger, ZZ-type
Pfam	PF00569	8.9E-7	19	51	IPR000433	Zinc finger, ZZ-type
SuperFamily	SSF57850	1.29E-12	19	82	No hit	No description
PROSITE pattern	PS01357	0	21	48	IPR000433	Zinc finger, ZZ-type
SuperFamily	SSF46689	1.72E-12	74	125	IPR009057	Homeodomain-like
PROSITE profile	PS51293	20.331	74	126	IPR017884	SANT domain
SMART	SM00717	2.0E-8	75	124	IPR001005	SANT/Myb domain
Pfam	PF00249	9.9E-11	78	120	IPR001005	SANT/Myb domain
Gene3D	G3DSA:1.10.10.60	1.8E-8	78	121	IPR009057	Homeodomain-like
CDD	cd00167	3.46E-9	79	121	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006357	Biological Process	regulation of transcription from RNA polymerase II promoter
GO:0016573	Biological Process	histone acetylation
GO:0003677	Molecular Function	DNA binding
GO:0008270	Molecular Function	zinc ion binding

Sequence ? help Back to Top
Protein Sequence Length: 308 aa Download sequence Send to blast
METAYAGEGQ TVREEKVFYQ CNYCNKDIYR KIHIKCLRCS DFNLCVECFS VAAEVYPHRS 60 NHPYTVMDNL FFPLMCTDWN AKEELLLLEG IKMYGFGNWY EVAEHVGTKD RTQCLDHYNS 120 IYVHSPCVPV QEKYTEHLSM AHRQIIKDCN AEGSVREKQA RTSVEFVTEY GNDAQQLLAD 180 IEFKETDTDD ERELKLRVLR FYSKRLDERK CRKKFLLERN LLHPHLVETY LSPEEKEICR 240 PYRVFMRYHS TEEHANLLRT VVEEHRIRKR IQDLKDARAA GCRTPTEVER YIEQKSKRMK 300 ESTRAGPC

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
6cw3_E	7e-24	19	132	5	118	Transcriptional adapter 2
6cw3_G	7e-24	19	132	5	118	Transcriptional adapter 2
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Functional Description ? help Back to Top
Source	Description
UniProt	Required for the function of some acidic activation domains, which activate transcription from a distant site. The exact mechanism of action is not yet known (By similarity). ADA2 stimulates the acetyltransferase activity of GCN5 on free histones or nucleosomes, probably by opening up the promoter region. Mediates auxin and cytokinin signals in the control of cell proliferation and might be involved in repression of a freezing tolerance pathway at warm temperature (PubMed:12615937, PubMed:12747832). Involved in the positive regulation of salt-induced gene expression by maintaining locus-specific acetylation of histones H4 and H3 (PubMed:21193996). {ECO:0000250, ECO:0000269\|PubMed:12615937, ECO:0000269\|PubMed:12747832, ECO:0000269\|PubMed:21193996}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_027064377.1	1e-128	transcriptional adapter ADA2-like isoform X1
Swissprot	Q9ATB4	1e-104	TAD2B_ARATH; Transcriptional adapter ADA2b
TrEMBL	A0A103XLY9	1e-129	A0A103XLY9_CYNCS; Transcriptional adapter
STRING	XP_006467294.1	1e-113	(Citrus sinensis)

Publications ? help Back to Top
Vlachonasios KE,Thomashow MF,Triezenberg SJ Disruption mutations of ADA2b and GCN5 transcriptional adaptor genes dramatically affect Arabidopsis growth, development, and gene expression. Plant Cell, 2003. 15(3): p. 626-38 [PMID:12615937] Sieberer T,Hauser MT,Seifert GJ,Luschnig C PROPORZ1, a putative Arabidopsis transcriptional adaptor protein, mediates auxin and cytokinin signals in the control of cell proliferation. Curr. Biol., 2003. 13(10): p. 837-42 [PMID:12747832] Kerschen A,Napoli CA,Jorgensen RA,Müller AE Effectiveness of RNA interference in transgenic plants. FEBS Lett., 2004. 566(1-3): p. 223-8 [PMID:15147899] Hark AT, et al. Two Arabidopsis orthologs of the transcriptional coactivator ADA2 have distinct biological functions. Biochim. Biophys. Acta, 2009. 1789(2): p. 117-24 [PMID:18929690] Anzola JM, et al. Putative Arabidopsis transcriptional adaptor protein (PROPORZ1) is required to modulate histone acetylation in response to auxin. Proc. Natl. Acad. Sci. U.S.A., 2010. 107(22): p. 10308-13 [PMID:20479223] Kaldis A,Tsementzi D,Tanriverdi O,Vlachonasios KE Arabidopsis thaliana transcriptional co-activators ADA2b and SGF29a are implicated in salt stress responses. Planta, 2011. 233(4): p. 749-62 [PMID:21193996] Vlachonasios KE,Kaldis A,Nikoloudi A,Tsementzi D The role of transcriptional coactivator ADA2b in Arabidopsis abiotic stress responses. Plant Signal Behav, 2011. 6(10): p. 1475-8 [PMID:21897124] Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Kazama D,Kurusu T,Mitsuda N,Ohme-Takagi M,Tada Y Involvement of elevated proline accumulation in enhanced osmotic stress tolerance in Arabidopsis conferred by chimeric repressor gene silencing technology. Plant Signal Behav, 2014. 9(3): p. e28211 [PMID:24614501] Kim JY,Oh JE,Noh YS,Noh B Epigenetic control of juvenile-to-adult phase transition by the Arabidopsis SAGA-like complex. Plant J., 2015. 83(3): p. 537-45 [PMID:26095998] Kazama D, et al. Identification of Chimeric Repressors that Confer Salt and Osmotic Stress Tolerance in Arabidopsis. Plants (Basel), 2013. 2(4): p. 769-85 [PMID:27137403] Simon MK,Skinner DJ,Gallagher TL,Gasser CS Integument Development in Arabidopsis Depends on Interaction of YABBY Protein INNER NO OUTER with Coactivators and Corepressors. Genetics, 2017. 207(4): p. 1489-1500 [PMID:28971961] Lai J, et al. The Transcriptional Coactivator ADA2b Recruits a Structural Maintenance Protein to Double-Strand Breaks during DNA Repair in Plants. Plant Physiol., 2018. 176(4): p. 2613-2622 [PMID:29463775] Kotak J, et al. The histone acetyltransferase GCN5 and the transcriptional coactivator ADA2b affect leaf development and trichome morphogenesis in Arabidopsis. Planta, 2018. 248(3): p. 613-628 [PMID:29846775]