PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID evm.model.supercontig_35.34
Organism
Carica papaya
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Caricaceae; Carica
Family E2F/DP
Protein Properties Length: 358aa    MW: 39786.6 Da    PI: 8.0977
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
evm.model.supercontig_35.34genomeASGPBView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP73.91.7e-231580171
                      E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                                 rk+ksL+ll+++fl+l++++  + + l+++a++L    v  +rRRiYDi+NVLe+++++++++kn+++wkg
  evm.model.supercontig_35.34 15 RKQKSLGLLCTNFLTLYNREGIDLIGLDDAATKL---GV--ERRRIYDIVNVLESVGVLTRRAKNQYTWKG 80
                                 79*****************999************...**..****************************98 PP
2E2F_TDP77.41.3e-24151231171
                      E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                                  r+eksL+lltq+f+kl+ +++++ ++l+e+a+ L+ +      +++k+RR+YDi+NVL+++nliek     ++k+++rw g
  evm.model.supercontig_35.34 151 RREKSLGLLTQNFVKLFVCTDANLISLDEAARLLLGDahntsIMRTKVRRLYDIANVLSSMNLIEKthtsdTRKPAFRWLG 231
                                  689**************************************999**************************99*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.106.2E-261182IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.6E-161478IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.4E-271580IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.3E-201680IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.107.2E-23147232IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.2E-31151231IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.1E-19153231IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467854.42E-14153232IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 358 aa     Download sequence    Send to blast
MNLYDSASRH HAYSRKQKSL GLLCTNFLTL YNREGIDLIG LDDAATKLGV ERRRIYDIVN  60
VLESVGVLTR RAKNQYTWKG FDAIPKALKE LKDEGLKDNL HSFDGNSNAK ISDDDEDDDE  120
GLSNPNTGSQ NDGSKPSSVL KPSASSKMDN RREKSLGLLT QNFVKLFVCT DANLISLDEA  180
ARLLLGDAHN TSIMRTKVRR LYDIANVLSS MNLIEKTHTS DTRKPAFRWL GFGGKSENTS  240
RDALVLESRK RAFGTDVTNI SCKKSIVEFS IDDHMNPSLK MQKQPTVESL VNRSKLESDS  300
RQGSKSYHFG PFAPVGIPKS GGLENNANQV LDLENLASTH KPQYHNQGNI ERDPEPE*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A6e-40142233228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapevm.model.supercontig_35.34
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021900835.10.0E2F transcription factor-like E2FE isoform X2
SwissprotQ8LSZ41e-148E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A061FTS01e-171A0A061FTS0_THECC; DP-E2F-like 1 isoform 1
STRINGevm.model.supercontig_35.340.0(Carica papaya)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM63042743
Representative plantOGRP24741634
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.11e-152DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]