PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID evm_27.model.AmTr_v1.0_scaffold00001.504
Common NameAMTR_s00001p00272070, LOC18424562
Organism
Amborella trichopoda
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; basal Magnoliophyta; Amborellales; Amborellaceae; Amborella
Family bHLH
Protein Properties Length: 390aa    MW: 43205.8 Da    PI: 7.08
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
evm_27.model.AmTr_v1.0_scaffold00001.504genomeTAGPView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH39.69.6e-13187238155
                                               CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
                                       HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                                               +r++h ++Er+RR+++N+ ++ Lr+l+P +     ++ + a+i   A++++k+L+
  evm_27.model.AmTr_v1.0_scaffold00001.504 187 QRMTHIAVERNRRKQMNEHLNALRSLMPAS---FIQRGDQASIIGGAIDFVKELE 238
                                               79***************************9...9******************995 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000831.58E-13185242No hitNo description
PROSITE profilePS5088815.491186237IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474592.36E-16186255IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000103.9E-10187238IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.102.0E-14187251IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003535.3E-11192243IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 390 aa     Download sequence    Send to blast
MQGPIDPCCL QAFVEHQTLE CLDQGNGVDL GAPAWAPTLG AEGLRLGDNW FTSFCSLSPQ  60
KSAMPNLSFL NILEPARASG LCPYFMDSSH IQALELESCI THVSETYSPE KPGAKDIRKL  120
EEAASSVNRE PNSPENGRDH NSGSSSGWVR ELRAQPEAKH LSTGAVRERK KRKRSKACKN  180
SREVESQRMT HIAVERNRRK QMNEHLNALR SLMPASFIQR GDQASIIGGA IDFVKELEQL  240
LQSLQAKKQT RQSEEGYSPT SSTVPFNGFF SSPQYTTYSN FKYMVDGLMD QRGNEFKAEN  300
KSAVADIEVT LIQTHANLKI LSPRRPGQLL KTIAALENLE LTILHLNITT IQHSVLYSFN  360
LKIEEGCKLG SADEIAAAVH QIFSFINEN*
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1168173RKKRKR
2169174KKRKRS
3187198RMTHIAVERNRR
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006829211.10.0transcription factor bHLH94 isoform X1
SwissprotQ56YJ82e-66FAMA_ARATH; Transcription factor FAMA
TrEMBLW1NLC00.0W1NLC0_AMBTC; Uncharacterized protein
STRINGERM966270.0(Amborella trichopoda)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP25315131
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G24140.19e-69bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Amborella Genome Project
    The Amborella genome and the evolution of flowering plants.
    Science, 2013. 342(6165): p. 1241089
    [PMID:24357323]
  3. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  4. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  5. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  6. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  7. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]