PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID maker-scaffold13322-augustus-gene-0.2-mRNA-2
Organism
Castanea mollissima
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fagales; Fagaceae; Castanea
Family E2F/DP
Protein Properties Length: 496aa    MW: 54614.5 Da    PI: 4.6939
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
maker-scaffold13322-augustus-gene-0.2-mRNA-2genomeTHGPView Nucleic Acid
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP84.39.3e-27170235171
                                       E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekn 65 
                                                   r+++sL+llt+kf++ll+++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn
  maker-scaffold13322-augustus-gene-0.2-mRNA-2 170 RYDSSLGLLTKKFINLLKQAEDGNLDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKN 229
                                                   6899******************************...99..************************ PP

                                       E2F_TDP  66 eirwkg 71 
                                                   +i+wkg
  maker-scaffold13322-augustus-gene-0.2-mRNA-2 230 RIHWKG 235
                                                   ****98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.3E-28168237IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467853.63E-17170233IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.8E-34170235IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.5E-24172235IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146606.78E-46246352No hitNo description
SuperFamilySSF1440741.62E-31249352No hitNo description
PfamPF164213.0E-32251350IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 496 aa     Download sequence    Send to blast
MSGGARAPNR PAPPPPTVAS QILPPPPPMK RNLAVLASTK PPFVPPDDYH RFSSVVADRE  60
AEALVVRSPI DSDDCVLVVW HEASGCLFVL GGLLLLKRKN GTDDNEVQSI DWTNSPGYTS  120
VVNSPLKTPV SAKGGRIYNR SKGTKGNRSG PQTPVSNAGS PSPLTPGSCR YDSSLGLLTK  180
KFINLLKQAE DGNLDLNKAA ETLEVQKRRI YDITNVLEGI GLIEKKLKNR IHWKGLDALR  240
PGEVEDDASV LQAEVENLTN QEQRLDDQIR EMQERLRDLS EDENKKKWLF VTKEDIKGLP  300
CLQNETLLAI KAPHGTTLEV PDPDEAVDYP QRRYRVILRS AMGPIDVYLV SQFEEKFEEM  360
NSVEPPVSFP MVSSSGSNDN PATDEVVNAN STMKDVMPQA QHSHQMCSDL NASQEFPGGM  420
MKIVPSDVDN DADYWLLSDA EVSITDMWKT DAGIEWSGMD MLHPDFGIPD VSTPRSQTPL  480
SGMAEVPSTA FDSTRR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A7e-24166236274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00293DAPTransfer from AT2G36010Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_023886542.10.0transcription factor E2FA isoform X1
SwissprotQ9FNY01e-164E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A2N9ILM90.0A0A2N9ILM9_FAGSY; Uncharacterized protein
STRINGEMJ055330.0(Prunus persica)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-169E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]