PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID orange1.1g042344m
Common NameCISIN_1g042344mg
Organism
Citrus sinensis
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus
Family E2F/DP
Protein Properties Length: 303aa    MW: 34204 Da    PI: 6.2636
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
orange1.1g042344mgenomeICGCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP79.43.3e-2574154171
            E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                        r+eksL+lltq+f++l+ +s+ +++tl+evak L+ +      +++k+RR+YDi+NVL+++nliek     ++k+++rw g
  orange1.1g042344m  74 RREKSLGLLTQNFVRLFVCSNVDMITLDEVAKLLLGDahntsVMRTKVRRLYDIANVLSSMNLIEKthtadTRKPAFRWLG 154
                        689**************************************999**************************99*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.8E-2469156IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013724.3E-3174154IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023193.8E-2076154IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467855.44E-1476155IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 303 aa     Download sequence    Send to blast
MIGSRPEDAF TTLDGGNSAK VGQNRFTMFF FIFWGSDDED DDEDDDSSSN PNPGSQSDSL  60
NPRSAHKSSK NDSRREKSLG LLTQNFVRLF VCSNVDMITL DEVAKLLLGD AHNTSVMRTK  120
VRRLYDIANV LSSMNLIEKT HTADTRKPAF RWLGVNRLEI GLADSLNLDE SRKRTFGTDV  180
TNISFKRKRM DTSINGDISQ SIKMEKQMKV DDLVRVVDGS NSENYVNQGP RSYQFGPFAP  240
ESVPEVNTSK NNVKGAHDWE SLTSKYCPQY HNQALRDLFS HYMEAWQSWY TEVAGKTIRQ  300
IS*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A1e-1643146118228Transcription factor E2F8
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1171188RKRTFGTDVTNISFKRKR
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected during early S phase. Expressed at both the G1/S and S/G2 transitions, with a peak during G2. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:18787127}.
UniprotTISSUE SPECIFICITY: Expressed exclusively in mitotically dividing cells. Highly expressed in young leaves and mature flowers. Lower expression in young stalk and in young and mature flowers. {ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366}.
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024044442.10.0E2F transcription factor-like E2FE
SwissprotQ8LSZ43e-73E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A067G2W90.0A0A067G2W9_CITSI; Uncharacterized protein
STRINGXP_006476685.10.0(Citrus sinensis)
STRINGXP_006439729.10.0(Citrus clementina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM63042743
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.26e-73DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]